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BET4 Rab geranylgeranyltransferase BET4 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853421, updated on 3-Jun-2026
Official Symbol
BET4
Official Full Name
Rab geranylgeranyltransferase BET4
Primary source
SGD:S000003568
Locus tag
YJL031C
See related
AllianceGenome:SGD:S000003568; FungiDB:YJL031C; VEuPathDB:YJL031C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables Rab geranylgeranyltransferase activity. Involved in endoplasmic reticulum to Golgi vesicle-mediated transport; protein geranylgeranylation; and protein targeting to membrane. Located in peroxisome. Part of Rab-protein geranylgeranyltransferase complex. Orthologous to human RABGGTA (Rab geranylgeranyltransferase subunit alpha). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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Location:
chromosome: X
Exon count:
2
Sequence:
Chromosome: X; NC_001142.9 (386368..387438, complement)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Hsp70 family ATPase KAR2 Neighboring gene RNA-dependent ATPase HCA4 Neighboring gene spindle checkpoint protein MAD2 Neighboring gene Vps53p

Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Bet2p and Mad2p are components of a prenyltransferase that adds geranylgeranyl onto Ypt1p and Sec4p. Jiang Y, et al. Nature, 1993 Nov 4. PMID 8232542
  2. Characterization of yeast type-II geranylgeranyltransferase. Jiang Y, et al. Methods Enzymol, 1995. PMID 8583924
  3. Yeast geranylgeranyltransferase type-II: steady state kinetic studies of the recombinant enzyme. Witter DJ, et al. Biochemistry, 1996 Aug 13. PMID 8756702
  4. Feedback control of mitosis in budding yeast. Li R, et al. Cell, 1991 Aug 9. PMID 1651172
  5. The mitotic feedback control gene MAD2 encodes the alpha-subunit of a prenyltransferase. Li R, et al. Nature, 1993 Nov 4. PMID 8232541

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables Rab geranylgeranyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables Rab geranylgeranyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein geranylgeranyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein prenyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables small GTPase binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein geranylgeranylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein geranylgeranylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein targeting to membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Rab-protein geranylgeranyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Rab-protein geranylgeranyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Rab-protein geranylgeranyltransferase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol HDA PubMed 
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
Rab geranylgeranyltransferase BET4
NP_012503.2
  • Alpha subunit of Type II geranylgeranyltransferase; required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    386368..387438 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181465.1 → NP_012503.2  Rab geranylgeranyltransferase BET4

    See identical proteins and their annotated locations for NP_012503.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWF1, Q00618
    UniProtKB/TrEMBL
    A6ZPU4, C8ZBC8, G2WGY6
    Conserved Domains (1) summary
    COG5536
    Location:1 → 327
    BET4; Protein prenyltransferase, alpha subunit [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q00618.3

Gene LinkOut

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