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TAD2 tRNA(adenine34) deaminase [ Saccharomyces cerevisiae S288C ]

Gene ID: 853417, updated on 4-Feb-2026
Official Symbol
TAD2
Official Full Name
tRNA(adenine34) deaminase
Primary source
SGD:S000003572
Locus tag
YJL035C
See related
AllianceGenome:SGD:S000003572; FungiDB:YJL035C; VEuPathDB:YJL035C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables tRNA-specific adenosine deaminase activity. Involved in tRNA modification. Located in cytoplasm and nucleus. Orthologous to human ADAT2 (adenosine deaminase tRNA specific 2). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See TAD2 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (380249..381001, complement)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene tRNA-Val Neighboring gene Snx4p Neighboring gene Hsp70 family ATPase KAR2 Neighboring gene RNA-dependent ATPase HCA4

Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Mechanism, specificity and general properties of the yeast enzyme catalysing the formation of inosine 34 in the anticodon of transfer RNA. Auxilien S, et al. J Mol Biol, 1996 Oct 4. PMID 8893855
  2. The CGA codon decoding through tRNA(Arg) (ICG) supply governed by Tad2/Tad3 in Saccharomyces cerevisiae. Wada M, et al. FEBS J, 2023 Jul. PMID 36806932
  3. An adenosine deaminase that generates inosine at the wobble position of tRNAs. Gerber AP, et al. Science, 1999 Nov 5. PMID 10550050
  4. Crystal structure of the yeast heterodimeric ADAT2/3 deaminase. Liu X, et al. BMC Biol, 2020 Dec 3. PMID 33272269, Free PMC Article
  5. Mutator effects and mutation signatures of editing deaminases produced in bacteria and yeast. Lada AG, et al. Biochemistry (Mosc), 2011 Jan. PMID 21568845, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The CGA codon decoding through tRNA[Arg] (ICG) supply governed by Tad2/Tad3 in Saccharomyces cerevisiae.
    Title: The CGA codon decoding through tRNA(Arg) (ICG) supply governed by Tad2/Tad3 in Saccharomyces cerevisiae.
  2. Crystal structure of the ADAT2-ADAT3 heterodimer. [ADAT2, ADAT3]
    Title: Biochemical and structural studies of A-to-I editing by tRNA:A34 deaminases at the wobble position of transfer RNA.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables tRNA-specific adenosine deaminase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables tRNA-specific adenosine deaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA-specific adenosine-34 deaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA-specific adenosine-34 deaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in tRNA modification IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA wobble adenosine to inosine editing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA wobble adenosine to inosine editing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in tRNA wobble adenosine to inosine editing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of tRNA-specific adenosine-34 deaminase complex IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
tRNA(adenine34) deaminase
NP_012499.1
  • Subunit of tRNA-specific adenosine-34 deaminase; forms a heterodimer with Tad3p that converts adenosine to inosine at the wobble position of several tRNAs

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    380249..381001 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181469.1 → NP_012499.1  tRNA(adenine34) deaminase

    See identical proteins and their annotated locations for NP_012499.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWE8, P47058
    UniProtKB/TrEMBL
    A6ZPU1, G2WGY3
    Conserved Domains (1) summary
    COG0590
    Location:1 → 159
    TadA; tRNA(Arg) A34 adenosine deaminase TadA [Translation, ribosomal structure and biogenesis]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P47058.1

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