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CHST1 carbohydrate sulfotransferase 1 [ Homo sapiens (human) ]

Gene ID: 8534, updated on 7-Jun-2020

Summary

Official Symbol
CHST1provided by HGNC
Official Full Name
carbohydrate sulfotransferase 1provided by HGNC
Primary source
HGNC:HGNC:1969
See related
Ensembl:ENSG00000175264 MIM:603797
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C6ST; KSST; GST-1; KS6ST; KSGal6ST
Summary
This locus encodes a member of the keratin sulfotransferase family of proteins. The encoded enzyme catalyzes the sulfation of the proteoglycan keratin. [provided by RefSeq, Aug 2011]
Expression
Biased expression in brain (RPKM 12.8), thyroid (RPKM 2.7) and 6 other tissues See more
Orthologs

Genomic context

See CHST1 in Genome Data Viewer
Location:
11p11.2
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (45647689..45665651, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (45669239..45687206, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376655 Neighboring gene uncharacterized LOC105376656 Neighboring gene microRNA 7154 Neighboring gene uncharacterized LOC100507384

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of carbohydrate (keratan sulfate Gal-6) sulfotransferase 1 (CHST1) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed
Knockdown of carbohydrate (keratan sulfate Gal-6) sulfotransferase 1 (CHST1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env Sulfate is linked to the carbohydrate chains of HIV-1 glycoproteins gp160, gp120, and gp41 during the endoplasmic reticulum to Golgi transport of the glycoproteins PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
N-acetylglucosamine 6-O-sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
keratan sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
keratan sulfotransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
keratan sulfotransferase activity TAS
Traceable Author Statement
more info
 
sulfotransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
N-acetylglucosamine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
galactose metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
keratan sulfate biosynthetic process TAS
Traceable Author Statement
more info
 
keratan sulfate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
keratan sulfate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
polysaccharide metabolic process TAS
Traceable Author Statement
more info
PubMed 
sulfur compound metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sulfur compound metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Golgi membrane TAS
Traceable Author Statement
more info
 
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
carbohydrate sulfotransferase 1
Names
Keratan sulfotransferase
carbohydrate (chondroitin 6/keratan) sulfotransferase 1
carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 1
NP_003645.1
XP_006718419.1
XP_016873948.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029811.1 RefSeqGene

    Range
    5035..22968
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003654.6NP_003645.1  carbohydrate sulfotransferase 1 precursor

    See identical proteins and their annotated locations for NP_003645.1

    Status: REVIEWED

    Source sequence(s)
    AC087442, AI793094, BC022567, BI917296, DA193787, DB493321
    Consensus CDS
    CCDS7913.1
    UniProtKB/Swiss-Prot
    O43916
    Related
    ENSP00000309270.2, ENST00000308064.7
    Conserved Domains (1) summary
    pfam00685
    Location:198384
    Sulfotransfer_1; Sulfotransferase domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    45647689..45665651 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017018459.2XP_016873948.1  carbohydrate sulfotransferase 1 isoform X1

    Conserved Domains (1) summary
    pfam00685
    Location:60384
    Sulfotransfer_1; Sulfotransferase domain
  2. XM_006718356.4XP_006718419.1  carbohydrate sulfotransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_006718419.1

    Conserved Domains (1) summary
    pfam00685
    Location:60384
    Sulfotransfer_1; Sulfotransferase domain

RNA

  1. XR_001748013.1 RNA Sequence

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