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JEM1 Jem1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853372, updated on 22-Sep-2022

Summary

Gene symbol
JEM1
Gene description
Jem1p
Primary source
SGD:S000003609
Locus tag
YJL073W
See related
AllianceGenome:SGD:S000003609
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
KAR8
Summary
Enables chaperone binding activity and unfolded protein binding activity. Involved in karyogamy involved in conjugation with cellular fusion; protein folding in endoplasmic reticulum; and ubiquitin-dependent ERAD pathway. Located in endoplasmic reticulum and nuclear outer membrane-endoplasmic reticulum membrane network. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See JEM1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (303181..305118)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Net1p Neighboring gene Apq13p Neighboring gene cohesin subunit SMC3 Neighboring gene DNA replication protein PSF2 Neighboring gene acetyl-CoA:L-glutamate N-acetyltransferase

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables chaperone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables chaperone binding IGI
Inferred from Genetic Interaction
more info
PubMed 
enables misfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables unfolded protein binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear outer membrane-endoplasmic reticulum membrane network IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Jem1p
NP_012462.3
  • DnaJ-like chaperone required for nuclear membrane fusion during mating; localizes to the ER membrane; exhibits genetic interactions with KAR2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    303181..305118
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181506.3NP_012462.3  TPA: Jem1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012462.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWB0, P40358
    UniProtKB/TrEMBL
    A0A8H4BZL1, N1P337
    Conserved Domains (1) summary
    COG0484
    Location:536644
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]