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SMC3 cohesin subunit SMC3 [ Saccharomyces cerevisiae S288c ]

Gene ID: 853371, updated on 17-Feb-2017
Gene symbol
SMC3
Gene description
cohesin subunit SMC3
Primary source
SGD:S000003610
Locus tag
YJL074C
Gene type
protein coding
RNA name
cohesin subunit SMC3
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288c (strain: S288c)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
See SMC3 in Map Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (299157..302849, complement)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene Ics3p Neighboring gene Net1p Neighboring gene Jem1p Neighboring gene DNA replication protein PSF2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Cell cycle - yeast, organism-specific biosystem (from KEGG)
    Cell cycle - yeast, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps (G1 and G2 phases). G1, S, and G...
  • Cell cycle - yeast, conserved biosystem (from KEGG)
    Cell cycle - yeast, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps (G1 and G2 phases). G1, S, and G...
  • Meiosis - yeast, organism-specific biosystem (from KEGG)
    Meiosis - yeast, organism-specific biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, one pair of sister chromatids recombines with, th...
  • Meiosis - yeast, conserved biosystem (from KEGG)
    Meiosis - yeast, conserved biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, one pair of sister chromatids recombines with, th...
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to ATPase activity IDA
Inferred from Direct Assay
more info
PubMed 
chromatin binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
DNA repair IEA
Inferred from Electronic Annotation
more info
 
ascospore formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
chromosome organization IEA
Inferred from Electronic Annotation
more info
 
meiotic sister chromatid cohesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic nuclear division IEA
Inferred from Electronic Annotation
more info
 
mitotic sister chromatid cohesion IEA
Inferred from Electronic Annotation
more info
 
mitotic sister chromatid cohesion IGI
Inferred from Genetic Interaction
more info
PubMed 
reciprocal meiotic recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
replication-born double-strand break repair via sister chromatid exchange IMP
Inferred from Mutant Phenotype
more info
PubMed 
synaptonemal complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
chromosome IEA
Inferred from Electronic Annotation
more info
 
cohesin complex IEA
Inferred from Electronic Annotation
more info
 
nuclear mitotic cohesin complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
Names
cohesin subunit SMC3
NP_012461.1
  • Subunit of the multiprotein cohesin complex; required for sister chromatid cohesion in mitotic cells; also required, with Rec8p, for cohesion and recombination during meiosis; phylogenetically conserved SMC chromosomal ATPase family member

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    299157..302849 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181507.1NP_012461.1  TPA: cohesin subunit SMC3 [Saccharomyces cerevisiae S288c]

    See identical proteins and their annotated locations for NP_012461.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P47037
    Conserved Domains (4) summary
    cd03272
    Location:3174
    ABC_SMC3_euk; ATP-binding cassette domain of eukaryotic SMC3 proteins
    smart00968
    Location:534650
    SMC_hinge; SMC proteins Flexible Hinge Domain
    COG1196
    Location:11221
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl21455
    Location:11141209
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
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