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ARP4 Arp4p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853364, updated on 18-Sep-2024

Summary

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Official Symbol
ARP4
Official Full Name
Arp4p
Primary source
SGD:S000003617
Locus tag
YJL081C
See related
AllianceGenome:SGD:S000003617; FungiDB:YJL081C; VEuPathDB:YJL081C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
ACT3
Summary
Enables ATP binding activity and nucleosomal histone binding activity. Contributes to histone acetyltransferase activity. Involved in several processes, including DNA repair; chromosome organization; and histone acetylation. Located in chromatin and nucleus. Part of Ino80 complex; NuA4 histone acetyltransferase complex; and Swr1 complex. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 76. Orthologous to several human genes including ACTL6B (actin like 6B). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See ARP4 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (283802..285271, complement)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Tax4p Neighboring gene Iml2p Neighboring gene Scp160p Neighboring gene sterol-binding protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The nuclear actin-related protein Act3p/Arp4p is involved in the dynamics of chromatin-modulating complexes. Sunada R, et al. Yeast, 2005 Jul 30. PMID 16088870
  2. Further characterization of the actin-related protein Act3p/Arp4 of S. cerevisiae through mutational analysis. Stefanov SA. Mol Biol Rep, 2000 Mar. PMID 10939524
  3. Epigenetic effects on yeast transcription caused by mutations in an actin-related protein present in the nucleus. Jiang YW, et al. Genes Dev, 1996 Mar 1. PMID 8598290
  4. The actin-related protein Act3p of Saccharomyces cerevisiae is located in the nucleus. Weber V, et al. Mol Biol Cell, 1995 Oct. PMID 8573785, Free PMC Article
  5. Yeast Chromatin Mutants Reveal Altered mtDNA Copy Number and Impaired Mitochondrial Membrane Potential. Staneva D, et al. J Fungi (Basel), 2023 Mar 7. PMID 36983497, Free PMC Article

See all (132) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Actin-Related Protein 4 and Linker Histone Sustain Yeast Replicative Ageing.
    Title: Actin-Related Protein 4 and Linker Histone Sustain Yeast Replicative Ageing.
  2. Remarkably, Arp4, assisted by Arp8, influences actin polymerization in vitro and is able to depolymerize actin filaments.
    Title: Structural biochemistry of nuclear actin-related proteins 4 and 8 reveals their interaction with actin.
  3. N-terminal region of the Swr1 ATPase subunit is necessary and sufficient to direct association of Bdf1 and Swc7, as well as Arp4, Act1, Yaf9 and Swc4. This same region contains an additional H2AZ-H2B specific binding site.
    Title: N terminus of Swr1 binds to histone H2AZ and provides a platform for subunit assembly in the chromatin remodeling complex.
  4. Act3p/Arp4 is a key regulator in the maintenance of cellular shape and nuclear organization
    Title: The nuclear actin-related protein Act3p/Arp4 influences yeast cell shape and bulk chromatin organization.
  5. Results show that the deficiency of functional Arp4 caused a highly increased sensitivity towards nitrogen starvation and to the macrolide antibiotic rapamycin.
    Title: Novel regulatory properties of Saccharomyces cerevisiae Arp4.
  6. Arp4 directly binds to Esa1p. The interaction of Arp4 and Esa1p was not abolished by a deletion of one or both of the specific insertions present in the ARP4 gene.
    Title: The nuclear actin-related protein of Saccharomyces cerevisiae, Arp4, directly interacts with the histone acetyltransferase Esa1p.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA repair IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromatin remodeling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in kinetochore assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of Ino80 complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of NuA4 histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of NuA4 histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of SWI/SNF complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Swr1 complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intracellular non-membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Arp4p
NP_012454.1
  • Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    283802..285271 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181514.1 → NP_012454.1  TPA: Arp4p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012454.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWA2, P80428
    UniProtKB/TrEMBL
    A6ZPP3, B3LQ31, C7GR32, C8ZB79, G2WGT6, N1P193
    Conserved Domains (1) summary
    COG5277
    Location:9 → 488
    COG5277; Actin-related protein [Cytoskeleton]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P80428.1

Gene LinkOut

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