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GWT1 glucosaminyl-phosphotidylinositol O-acyltransferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 853354, updated on 5-Jul-2025
Official Symbol
GWT1
Official Full Name
glucosaminyl-phosphotidylinositol O-acyltransferase
Primary source
SGD:S000003627
Locus tag
YJL091C
See related
AllianceGenome:SGD:S000003627; FungiDB:YJL091C; VEuPathDB:YJL091C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables glucosaminyl-phosphatidylinositol O-acyltransferase activity. Involved in GPI anchor biosynthetic process. Located in membrane. Human ortholog(s) of this gene implicated in hyperphosphatasia with impaired intellectual development syndrome 5. Orthologous to human PIGW (phosphatidylinositol glycan anchor biosynthesis class W). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See GWT1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (261080..262552, complement)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Tok1p Neighboring gene DNA helicase SRS2 Neighboring gene protein kinase activating protein DPB11 Neighboring gene Sip4p

Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Medicinal genetics approach towards identifying the molecular target of a novel inhibitor of fungal cell wall assembly. Tsukahara K, et al. Mol Microbiol, 2003 May. PMID 12753194
  2. Sequence analysis of a 33.1 kb fragment from the left arm of Saccharomyces cerevisiae chromosome X, including putative proteins with leucine zippers, a fungal Zn(II)2-Cys6 binuclear cluster domain and a putative alpha 2-SCB-alpha 2 binding site. Miosga T, et al. Yeast, 1995 Jun 15. PMID 7483841
  3. GWT1 gene is required for inositol acylation of glycosylphosphatidylinositol anchors in yeast. Umemura M, et al. J Biol Chem, 2003 Jun 27. PMID 12714589
  4. Chemical Genomics-Based Antifungal Drug Discovery: Targeting Glycosylphosphatidylinositol (GPI) Precursor Biosynthesis. Mann PA, et al. ACS Infect Dis, 2015 Jan 9. PMID 26878058, Free PMC Article
  5. Analysis of membrane topology and identification of essential residues for the yeast endoplasmic reticulum inositol acyltransferase Gwt1p. Sagane K, et al. J Biol Chem, 2011 Apr 22. PMID 21367863, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. analysis of essential residues of PIG-W and Gwt1p and membrane topology of Gwt1p
    Title: Analysis of membrane topology and identification of essential residues for the yeast endoplasmic reticulum inositol acyltransferase Gwt1p.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables O-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glucosaminyl-phosphatidylinositol O-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glucosaminyl-phosphatidylinositol O-acyltransferase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables glucosaminyl-phosphatidylinositol O-acyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in GPI anchor biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in GPI anchor biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in GPI anchor biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in GPI anchor metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear outer membrane-endoplasmic reticulum membrane network HDA PubMed 
Preferred Names
glucosaminyl-phosphotidylinositol O-acyltransferase
NP_012444.2
  • Protein involved in the inositol acylation of GlcN-PI; the inositol acylation of glucosaminyl phosphatidylinositol (GlcN-PI) forms glucosaminyl(acyl)phosphatidylinositol (GlcN(acyl)PI), an intermediate in the biosynthesis of glycosylphosphatidylinositol (GPI) anchors

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    261080..262552 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181524.1 → NP_012444.2  TPA: glucosaminyl-phosphotidylinositol O-acyltransferase

    See identical proteins and their annotated locations for NP_012444.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VW93, P47026
    UniProtKB/TrEMBL
    B3LQ22, C7GR23, N1P186
    Conserved Domains (1) summary
    cl02109
    Location:4 → 490
    GWT1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P47026.2

Gene LinkOut

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