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GWT1 glucosaminyl-phosphotidylinositol O-acyltransferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 853354, updated on 14-Nov-2024

Summary

Official Symbol
GWT1
Official Full Name
glucosaminyl-phosphotidylinositol O-acyltransferase
Primary source
SGD:S000003627
Locus tag
YJL091C
See related
AllianceGenome:SGD:S000003627; FungiDB:YJL091C; VEuPathDB:YJL091C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables glucosaminyl-phosphatidylinositol O-acyltransferase activity. Involved in GPI anchor biosynthetic process. Located in membrane. Human ortholog(s) of this gene implicated in hyperphosphatasia with impaired intellectual development syndrome 5. Orthologous to human PIGW (phosphatidylinositol glycan anchor biosynthesis class W). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See GWT1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (261080..262552, complement)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Tok1p Neighboring gene DNA helicase SRS2 Neighboring gene protein kinase activating protein DPB11 Neighboring gene Sip4p

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

General protein information

Preferred Names
glucosaminyl-phosphotidylinositol O-acyltransferase
NP_012444.2
  • Protein involved in the inositol acylation of GlcN-PI; the inositol acylation of glucosaminyl phosphatidylinositol (GlcN-PI) forms glucosaminyl(acyl)phosphatidylinositol (GlcN(acyl)PI), an intermediate in the biosynthesis of glycosylphosphatidylinositol (GPI) anchors

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    261080..262552 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181524.1NP_012444.2  TPA: glucosaminyl-phosphotidylinositol O-acyltransferase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012444.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VW93, P47026
    UniProtKB/TrEMBL
    B3LQ22, C7GR23, N1P186
    Conserved Domains (1) summary
    cl02109
    Location:4490
    GWT1