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SRS2 DNA helicase SRS2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853353, updated on 12-Oct-2021

Summary

Gene symbol
SRS2
Gene description
DNA helicase SRS2
Primary source
SGD:S000003628
Locus tag
YJL092W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
HPR5
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Genomic context

See SRS2 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (257423..260947)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Kha1p Neighboring gene Tok1p Neighboring gene glucosaminyl-phosphotidylinositol O-acyltransferase Neighboring gene protein kinase activating protein DPB11

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables 3'-5' DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables 3'-5' DNA helicase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA helicase activity IEA
Inferred from Electronic Annotation
more info
 
enables enzyme activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables helicase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
DNA helicase SRS2
NP_012443.1
  • DNA helicase and DNA-dependent ATPase; role in DNA repair and checkpoint recovery, in the proper timing of commitment to meiotic recombination and the Meiosis I to II transition; blocks trinucleotide repeat expansion; affects genome stability; disassembles Rad51p nucleoprotein filaments during meiotic recombination; stimulates Mus81p-Mms4p endonuclease activity independent of catalytic activity; ATPase and ssDNA translocating motor activities inhibited by Dmc1p; functional homolog of human RTEL1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    257423..260947
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181525.1NP_012443.1  TPA: DNA helicase SRS2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012443.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P12954
    Conserved Domains (1) summary
    COG0210
    Location:13750
    UvrD; Superfamily I DNA or RNA helicase [Replication, recombination and repair]
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