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LSB6 1-phosphatidylinositol 4-kinase LSB6 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853345, updated on 3-Jun-2026
Official Symbol
LSB6
Official Full Name
1-phosphatidylinositol 4-kinase LSB6
Primary source
SGD:S000003636
Locus tag
YJL100W
See related
AllianceGenome:SGD:S000003636; FungiDB:YJL100W; VEuPathDB:YJL100W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables 1-phosphatidylinositol 4-kinase activity. Involved in phosphatidylinositol phosphate biosynthetic process. Located in fungal-type vacuole membrane and plasma membrane. Orthologous to human PI4K2A (phosphatidylinositol 4-kinase type 2 alpha) and PI4K2B (phosphatidylinositol 4-kinase type 2 beta). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See LSB6 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (237263..239086)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene tRNA-Arg Neighboring gene glutamate--cysteine ligase Neighboring gene Chs6p Neighboring gene Sap185p

Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Saccharomyces cerevisiae contains a Type II phosphoinositide 4-kinase. Shelton SN, et al. Biochem J, 2003 Apr 15. PMID 12523934, Free PMC Article
  2. Purification, characterization, and kinetic analysis of a 55-kDa form of phosphatidylinositol 4-kinase from Saccharomyces cerevisiae. Nickels JT Jr, et al. J Biol Chem, 1992 Aug 15. PMID 1322897
  3. Regulation of phosphatidylinositol 4-kinase from the yeast Saccharomyces cerevisiae by CDP-diacylglycerol. Nickels JT Jr, et al. J Biol Chem, 1994 Apr 15. PMID 8157627
  4. Photoaffinity labeling of the 45-kDa and 55-kDa forms of phosphatidylinositol 4-kinase from the yeast Saccharomyces cerevisiae. Nickels JT Jr, et al. J Biol Chem, 1993 Nov 15. PMID 8226954
  5. The Saccharomyces cerevisiae LSB6 gene encodes phosphatidylinositol 4-kinase activity. Han GS, et al. J Biol Chem, 2002 Dec 6. PMID 12361950

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 1-phosphatidylinositol 4-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1-phosphatidylinositol 4-kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 1-phosphatidylinositol 4-kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables 1-phosphatidylinositol 4-kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables 1-phosphatidylinositol 4-kinase activity RCA
inferred from Reviewed Computational Analysis
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphotransferase activity, alcohol group as acceptor IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endosome organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol phosphate biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphatidylinositol phosphate biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphatidylinositol phosphate biosynthetic process RCA
inferred from Reviewed Computational Analysis
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytosol RCA
inferred from Reviewed Computational Analysis
more info
  
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in fungal-type vacuole membrane HDA PubMed 
is_active_in fungal-type vacuole membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in fungal-type vacuole membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in vacuolar membrane EXP
Inferred from Experiment
more info
 PubMed 
located_in vacuolar membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
1-phosphatidylinositol 4-kinase LSB6
NP_012435.1
  • Type II phosphatidylinositol 4-kinase; binds Las17p, a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    237263..239086
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181533.1 → NP_012435.1  1-phosphatidylinositol 4-kinase LSB6

    See identical proteins and their annotated locations for NP_012435.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VW84, P42951
    UniProtKB/TrEMBL
    B3LQ13, C8ZB63, N1P178
    Conserved Domains (1) summary
    pfam00454
    Location:170 → 498
    PI3_PI4_kinase; Phosphatidylinositol 3- and 4-kinase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P42951.1

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