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TIF2 translation initiation factor eIF4A [ Saccharomyces cerevisiae S288C ]

Gene ID: 853303, updated on 23-Apr-2026
Official Symbol
TIF2
Official Full Name
translation initiation factor eIF4A
Primary source
SGD:S000003674
Locus tag
YJL138C
See related
AllianceGenome:SGD:S000003674; FungiDB:YJL138C; VEuPathDB:YJL138C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables RNA helicase activity and translation initiation factor activity. Involved in positive regulation of formation of translation preinitiation complex and translational initiation. Located in cytoplasmic stress granule and plasma membrane. Part of eukaryotic translation initiation factor 4F complex. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with hypotonia and speech delay. Orthologous to human EIF4A1 (eukaryotic translation initiation factor 4A1) and EIF4A2 (eukaryotic translation initiation factor 4A2). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See TIF2 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (153504..154691, complement)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene DNA-directed RNA polymerase II subunit RPB4 Neighboring gene mannosyltransferase YUR1 Neighboring gene glycogenin glucosyltransferase GLG2 Neighboring gene uncharacterized protein

Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The initiation factor eIF4A is involved in the response to lithium stress in Saccharomyces cerevisiae. Montero-Lomeli M, et al. J Biol Chem, 2002 Jun 14. PMID 11940596
  2. ATP hydrolysis by initiation factor 4A is required for translation initiation in Saccharomyces cerevisiae. Blum S, et al. Proc Natl Acad Sci U S A, 1992 Aug 15. PMID 1502180, Free PMC Article
  3. Translation initiation factor 4A from Saccharomyces cerevisiae: analysis of residues conserved in the D-E-A-D family of RNA helicases. Schmid SR, et al. Mol Cell Biol, 1991 Jul. PMID 2046664, Free PMC Article
  4. Expression of translation initiation factor 4A from yeast and mouse in Saccharomyces cerevisiae. Prat A, et al. Biochim Biophys Acta, 1990 Aug 27. PMID 2119809
  5. Translation in Saccharomyces cerevisiae: initiation factor 4A-dependent cell-free system. Blum S, et al. Proc Natl Acad Sci U S A, 1989 Aug. PMID 2668952, Free PMC Article

See all (139) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. mRNA- and factor-driven dynamic variability controls eIF4F-cap recognition for translation initiation.
    Title: mRNA- and factor-driven dynamic variability controls eIF4F-cap recognition for translation initiation.
  2. Findings that eIF4A functionally interacts with the pre-initiation complex and plays important roles beyond unwinding 5'-UTR structure is consistent with a recent proposal that eIF4A modulates the conformation of the 40S ribosomal subunit to promote mRNA recruitment.
    Title: Yeast eIF4A enhances recruitment of mRNAs regardless of their structural complexity.
  3. Findings suggest that Ded1 is critically required to promote scanning through secondary structures within 5' UTRs, and while eIF4A cooperates with Ded1 in this function, it also promotes a step of initiation common to virtually all yeast mRNAs.
    Title: Genome-wide analysis of translational efficiency reveals distinct but overlapping functions of yeast DEAD-box RNA helicases Ded1 and eIF4A.
  4. Overexpression of the translation initiation factor TIF2 increases the induction of HXT1 translation.
    Title: Expression of the glucose transporter HXT1 involves the Ser-Thr protein phosphatase Sit4 in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent activity, acting on RNA IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA helicase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA helicase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables translation initiation factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables translation initiation factor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in gene expression IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of formation of translation preinitiation complex IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of translational initiation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in translational initiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in translational initiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm HDA PubMed 
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic stress granule HDA PubMed 
part_of eukaryotic translation initiation factor 4F complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in plasma membrane HDA PubMed 
located_in ribosome NAS
Non-traceable Author Statement
more info
 PubMed 
Preferred Names
translation initiation factor eIF4A
NP_012397.1
  • Translation initiation factor eIF4A; DEAD-box RNA helicase that couples ATPase activity to mRNA binding and unwinding; ATP hydrolysis accelerates the recruitment of mRNA during 48S preinitiation complex (PIC) assembly; ATPase activity stimulated by either eIF4G1 or by the PIC in an eIF3g and eIFGi subunit-dependent manner, independent of eIF4E and eIF4G; subunit of the mRNA cap-binding protein complex (eIF4F) with eIF4E and eIF4G; protein abundance increases in response to DNA replication stress

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    153504..154691 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181571.1 → NP_012397.1  translation initiation factor eIF4A

    See identical proteins and their annotated locations for NP_012397.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A6ZQJ1, D6VW46, P10081
    UniProtKB/TrEMBL
    B3LRD4, C8ZCM2, G2WI87, N1P0H0, N1P0I8
    Conserved Domains (1) summary
    PTZ00424
    Location:10 → 394
    PTZ00424; helicase 45; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P10081.3

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Research Materials
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