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YAK1 serine/threonine protein kinase YAK1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853300, updated on 15-Mar-2026
Official Symbol
YAK1
Official Full Name
serine/threonine protein kinase YAK1
Primary source
SGD:S000003677
Locus tag
YJL141C
See related
AllianceGenome:SGD:S000003677; FungiDB:YJL141C; VEuPathDB:YJL141C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables protein serine/threonine kinase activity and protein tyrosine kinase activity. Involved in cAMP/PKA signal transduction. Located in cytoplasm and nucleus. Orthologous to human HIPK4 (homeodomain interacting protein kinase 4). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See YAK1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (147967..150390, complement)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Roq1p Neighboring gene protein transporter TIM17 Neighboring gene Irc9p Neighboring gene DNA-directed RNA polymerase II subunit RPB4 Neighboring gene mannosyltransferase YUR1

Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The Saccharomyces cerevisiae YAK1 gene encodes a protein kinase that is induced by arrest early in the cell cycle. Garrett S, et al. Mol Cell Biol, 1991 Aug. PMID 2072907, Free PMC Article
  2. Saccharomyces cerevisiae Yak1p protein kinase autophosphorylates on tyrosine residues and phosphorylates myelin basic protein on a C-terminal serine residue. Kassis S, et al. Biochem J, 2000 Jun 1. PMID 10816418, Free PMC Article
  3. Improved sensitivity for phosphopeptide mapping using capillary column HPLC and microionspray mass spectrometry: comparative phosphorylation site mapping from gel-derived proteins. Zappacosta F, et al. Anal Chem, 2002 Jul 1. PMID 12141686
  4. Interaction of the E1A oncoprotein with Yak1p, a novel regulator of yeast pseudohyphal differentiation, and related mammalian kinases. Zhang Z, et al. Mol Biol Cell, 2001 Mar. PMID 11251081, Free PMC Article
  5. Development of high-throughput phosphorylation profiling method for identification of Ser/Thr kinase specificity. Kim EM, et al. J Pept Sci, 2011 May. PMID 21480437

See all (101) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Yeast Puf3p-mediated mRNA decay is regulated by carbon source-specific differential interaction of Puf3p with Pop2p and Yak1p.
    Title: Yeast Puf3p-mediated mRNA decay is regulated by carbon source-specific differential interaction of Puf3p with Pop2p and Yak1p.
  2. ur data support the hypothesis that metabolic reprogramming to accumulate energy stores and the activation of anti-oxidant defence systems are coordinated by Yak1, Rim15 and Mck1 kinases to ensure quiescence entry and lifespan extension in yeast.
    Title: Chronological Lifespan in Yeast Is Dependent on the Accumulation of Storage Carbohydrates Mediated by Yak1, Mck1 and Rim15 Kinases.
  3. Yak1 is at the center of a regulatory cascade for adhesive growth and stress resistance
    Title: The Yak1 protein kinase lies at the center of a regulatory cascade affecting adhesive growth and stress resistance in Saccharomyces cerevisiae.
  4. Data discovered that six non-essential protein kinase (PKase) disruptions (Deltabck1, Deltamkk1, Deltaslt2/Deltampk1, Deltamck1, Deltassk2 and Deltayak1) suppressed the Cas-phenotype of the Deltaptp2 Deltamsg5 double disruptant.
    Title: Identification of protein kinase disruptions as suppressors of the calcium sensitivity of S. cerevisiae Deltaptp2 Deltamsg5 protein phosphatase double disruptant.
  5. Yak1 kinase phosphorylates and activates Hsf1 under the conditions of low PKA activity. It can also activate Msn2, possibly by direct phosphorylation.
    Title: Yeast Yak1 kinase, a bridge between PKA and stress-responsive transcription factors, Hsf1 and Msn2/Msn4.
  6. Over-expression of YAK1 decreased the growth rate, but only in the presence of a functional MSI1 gene.
    Title: Mutual interdependence of MSI1 (CAC3) and YAK1 in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity HDA PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cAMP/PKA signal transduction IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell-substrate adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
serine/threonine protein kinase YAK1
NP_012394.1
  • Serine-threonine protein kinase; component of a glucose-sensing system that inhibits growth in response to glucose availability; upon nutrient deprivation Yak1p phosphorylates Pop2p to regulate mRNA deadenylation, the co-repressor Crf1p to inhibit transcription of ribosomal genes, and the stress-responsive transcription factors Hsf1p and Msn2p; nuclear localization negatively regulated by the Ras/PKA signaling pathway in the presence of glucose

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    147967..150390 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181574.1 → NP_012394.1  serine/threonine protein kinase YAK1

    See identical proteins and their annotated locations for NP_012394.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VW43, P14680
    UniProtKB/TrEMBL
    B3LPX7, B5VL39, C8ZB77, N1P921
    Conserved Domains (1) summary
    cd14212
    Location:369 → 704
    PKc_YAK1; Catalytic domain of the Dual-specificity protein kinase, YAK1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P14680.1

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