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LGALS12 galectin 12 [ Homo sapiens (human) ]

Gene ID: 85329, updated on 7-Jun-2020

Summary

Official Symbol
LGALS12provided by HGNC
Official Full Name
galectin 12provided by HGNC
Primary source
HGNC:HGNC:15788
See related
Ensembl:ENSG00000133317 MIM:606096
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GAL12; GRIP1
Summary
This gene encodes a member of the galectin superfamily, a group of beta-galactoside-binding proteins with conserved carbohydrate recognition domains. The related mouse protein is a primary regulator of the early stages of adipose tissue development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, May 2010]
Expression
Biased expression in fat (RPKM 41.6) and bone marrow (RPKM 4.0) See more
Orthologs

Genomic context

See LGALS12 in Genome Data Viewer
Location:
11q12.3
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (63506052..63516772)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (63273524..63284246)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene solute carrier family 22 member 9 Neighboring gene zinc finger protein 91 pseudogene Neighboring gene phospholipase A and acyltransferase 5 Neighboring gene Sharpr-MPRA regulatory region 8142 Neighboring gene TMSB4X pseudogene 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
carbohydrate binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lactose binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lactose binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
intrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
lymphatic endothelial cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
regulation of lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
galectin-12
Names
galectin-related inhibitor of proliferation
lectin, galactoside-binding, soluble, 12
testicular secretory protein Li 26

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142535.2NP_001136007.2  galectin-12 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AP001591
    Consensus CDS
    CCDS44633.1
    Related
    ENSP00000501500.1, ENST00000674247.1
    Conserved Domains (1) summary
    smart00908
    Location:33159
    Gal-bind_lectin; Galactoside-binding lectin
  2. NM_001142536.2NP_001136008.2  galectin-12 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AP001591
    Consensus CDS
    CCDS53648.1
    Related
    ENSP00000255684.5, ENST00000255684.9
    Conserved Domains (1) summary
    smart00908
    Location:33158
    Gal-bind_lectin; Galactoside-binding lectin
  3. NM_001142537.2NP_001136009.1  galectin-12 isoform 4

    See identical proteins and their annotated locations for NP_001136009.1

    Status: REVIEWED

    Source sequence(s)
    AP001591
    Consensus CDS
    CCDS44634.1
    UniProtKB/Swiss-Prot
    Q96DT0
    Related
    ENSP00000394659.2, ENST00000415491.6
    Conserved Domains (1) summary
    smart00908
    Location:1119
    Gal-bind_lectin; Galactoside-binding lectin
  4. NM_001142538.2NP_001136010.1  galectin-12 isoform 5

    See identical proteins and their annotated locations for NP_001136010.1

    Status: REVIEWED

    Source sequence(s)
    AP001591
    Consensus CDS
    CCDS44635.1
    UniProtKB/Swiss-Prot
    Q96DT0
    Related
    ENSP00000399093.2, ENST00000425950.2
    Conserved Domains (1) summary
    smart00908
    Location:1119
    Gal-bind_lectin; Galactoside-binding lectin
  5. NM_033101.4NP_149092.3  galectin-12 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AP001591
    Consensus CDS
    CCDS8045.1
    Related
    ENSP00000378116.3, ENST00000394618.7
    Conserved Domains (1) summary
    smart00908
    Location:33158
    Gal-bind_lectin; Galactoside-binding lectin

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    63506052..63516772
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017018458.1XP_016873947.1  galectin-12 isoform X1

RNA

  1. XR_950085.2 RNA Sequence

  2. XR_950087.2 RNA Sequence

  3. XR_950086.1 RNA Sequence

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