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LGALS12 galectin 12 [ Homo sapiens (human) ]

Gene ID: 85329, updated on 17-Sep-2024

Summary

Official Symbol
LGALS12provided by HGNC
Official Full Name
galectin 12provided by HGNC
Primary source
HGNC:HGNC:15788
See related
Ensembl:ENSG00000133317 MIM:606096; AllianceGenome:HGNC:15788
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GAL12; GRIP1
Summary
This gene encodes a member of the galectin superfamily, a group of beta-galactoside-binding proteins with conserved carbohydrate recognition domains. The related mouse protein is a primary regulator of the early stages of adipose tissue development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, May 2010]
Expression
Biased expression in fat (RPKM 41.6) and bone marrow (RPKM 4.0) See more
Orthologs
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Genomic context

See LGALS12 in Genome Data Viewer
Location:
11q12.3
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (63506084..63516772)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (63495347..63506035)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (63273556..63284244)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene phospholipase A and acyltransferase 5 Neighboring gene uncharacterized LOC124902822 Neighboring gene uncharacterized LOC124902684 Neighboring gene NANOG hESC enhancer GRCh37_chr11:63268635-63269162 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr11:63270478-63271148 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:63277705-63278336 Neighboring gene TMSB4X pseudogene 5 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:63295415-63296076 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:63296739-63297398 Neighboring gene Sharpr-MPRA regulatory region 8142 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:63299385-63300044 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4869 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4870 Neighboring gene phospholipase A and acyltransferase 4 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:63312621-63313820

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables lactose binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables lactose binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in intrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within intrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
galectin-12
Names
galectin-related inhibitor of proliferation
lectin, galactoside-binding, soluble, 12
testicular secretory protein Li 26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142535.2NP_001136007.2  galectin-12 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AP001591
    Consensus CDS
    CCDS44633.2
    UniProtKB/TrEMBL
    A0A140VK26
    Related
    ENSP00000501500.1, ENST00000674247.1
    Conserved Domains (1) summary
    smart00908
    Location:33159
    Gal-bind_lectin; Galactoside-binding lectin
  2. NM_001142536.2NP_001136008.2  galectin-12 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AP001591
    Consensus CDS
    CCDS53648.2
    UniProtKB/Swiss-Prot
    B2R9N2, G5E970, Q96DS9, Q96DT0, Q96PR9, Q9H258, Q9H259, Q9NZ02
    UniProtKB/TrEMBL
    A0A6Q8JG94
    Related
    ENSP00000255684.6, ENST00000255684.10
    Conserved Domains (1) summary
    smart00908
    Location:33158
    Gal-bind_lectin; Galactoside-binding lectin
  3. NM_001142537.2NP_001136009.1  galectin-12 isoform 4

    See identical proteins and their annotated locations for NP_001136009.1

    Status: REVIEWED

    Source sequence(s)
    AP001591
    Consensus CDS
    CCDS44634.1
    UniProtKB/TrEMBL
    Q9NZ03
    Related
    ENSP00000394659.2, ENST00000415491.6
    Conserved Domains (1) summary
    smart00908
    Location:1119
    Gal-bind_lectin; Galactoside-binding lectin
  4. NM_001142538.2NP_001136010.1  galectin-12 isoform 5

    See identical proteins and their annotated locations for NP_001136010.1

    Status: REVIEWED

    Source sequence(s)
    AP001591
    Consensus CDS
    CCDS44635.1
    UniProtKB/TrEMBL
    Q9NZ03
    Related
    ENSP00000399093.2, ENST00000425950.2
    Conserved Domains (1) summary
    smart00908
    Location:1119
    Gal-bind_lectin; Galactoside-binding lectin
  5. NM_033101.4NP_149092.3  galectin-12 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AP001591
    Consensus CDS
    CCDS8045.2
    UniProtKB/Swiss-Prot
    B2R9N2, G5E970, Q96DS9, Q96DT0, Q96PR9, Q9H258, Q9H259, Q9NZ02
    Related
    ENSP00000378116.4, ENST00000394618.9
    Conserved Domains (1) summary
    smart00908
    Location:33158
    Gal-bind_lectin; Galactoside-binding lectin

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    63506084..63516772
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017018458.2XP_016873947.1  galectin-12 isoform X1

  2. XM_047427779.1XP_047283735.1  galectin-12 isoform X2

RNA

  1. XR_950085.3 RNA Sequence

  2. XR_950087.3 RNA Sequence

  3. XR_007062516.1 RNA Sequence

  4. XR_950086.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    63495347..63506035
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054370308.1XP_054226283.1  galectin-12 isoform X1

  2. XM_054370309.1XP_054226284.1  galectin-12 isoform X2

RNA

  1. XR_008488474.1 RNA Sequence

  2. XR_008488476.1 RNA Sequence

  3. XR_008488477.1 RNA Sequence

  4. XR_008488475.1 RNA Sequence