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TPK1 cAMP-dependent protein kinase catalytic subunit TPK1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853275, updated on 5-Sep-2021

Summary

Gene symbol
TPK1
Gene description
cAMP-dependent protein kinase catalytic subunit TPK1
Primary source
SGD:S000003700
Locus tag
YJL164C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
PKA1; SRA3
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Genomic context

See TPK1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (109966..111159, complement)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene ubiquinol--cytochrome-c reductase subunit 8 Neighboring gene protein kinase HAL5 Neighboring gene uncharacterized protein Neighboring gene Jjj2p

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the TPK1 gene: The TPK1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, M.oryzae, N.crassa, and frog.

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables AMP-activated protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables cAMP-dependent protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cAMP-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables cAMP-dependent protein kinase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables cAMP-dependent protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity HDA PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in Ras protein signal transduction IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in Ras protein signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cytoplasmic mRNA processing body assembly IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in peptidyl-serine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein kinase A signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein kinase A signaling IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in protein phosphorylation HDA PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of macroautophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of cAMP-dependent protein kinase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of cAMP-dependent protein kinase complex IGI
Inferred from Genetic Interaction
more info
PubMed 
part_of cAMP-dependent protein kinase complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in chromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cAMP-dependent protein kinase catalytic subunit TPK1
NP_012371.2
  • cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; phosphorylates and inhibits Whi3p to promote G1/S phase passage; partially redundant with Tpk2p and Tpk3p; phosphorylates pre-Tom40p, which impairs its import into mitochondria under non-respiratory conditions; TPK1 has a paralog, TPK3, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    109966..111159 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181597.2NP_012371.2  TPA: cAMP-dependent protein kinase catalytic subunit TPK1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012371.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P06244
    Conserved Domains (1) summary
    cd05580
    Location:85375
    STKc_PKA_like; Catalytic subunit of the Serine/Threonine Kinases, cAMP-dependent protein kinases
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