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QCR8 ubiquinol--cytochrome-c reductase subunit 8 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853273, updated on 19-Nov-2025
Official Symbol
QCR8
Official Full Name
ubiquinol--cytochrome-c reductase subunit 8
Primary source
SGD:S000003702
Locus tag
YJL166W
See related
AllianceGenome:SGD:S000003702; FungiDB:YJL166W; VEuPathDB:YJL166W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
COR5
Summary
Enables ubiquinol-cytochrome-c reductase activity. Involved in mitochondrial electron transport, ubiquinol to cytochrome c. Located in mitochondrion. Part of respiratory chain complex III. Human ortholog(s) of this gene implicated in mitochondrial complex III deficiency nuclear type 4. Orthologous to human UQCRQ (ubiquinol-cytochrome c reductase complex III subunit VII). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
all
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Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (106434..106718)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene histone methyltransferase SET2 Neighboring gene bifunctional (2E,6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase Neighboring gene protein kinase HAL5 Neighboring gene cAMP-dependent protein kinase catalytic subunit TPK1

Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The C-terminal half of the 11-kDa subunit VIII is not necessary for the enzymic activity of yeast ubiquinol:cytochrome-c oxidoreductase. Schoppink PJ, et al. Eur J Biochem, 1989 May 15. PMID 2543567
  2. Identification of ubiquinone-binding proteins in yeast mitochondrial ubiquinol-cytochrome c reductase using an azido-ubiquinone derivative. Yu L, et al. Biochim Biophys Acta, 1986 Mar 12. PMID 3004577
  3. Nucleotide sequence of the gene encoding the 11-kDa subunit of the ubiquinol-cytochrome-c oxidoreductase in Saccharomyces cerevisiae. Maarse AC, et al. Eur J Biochem, 1987 Jun 1. PMID 3036507
  4. Ubiquinone accumulates in the mitochondria of yeast mutated in the ubiquinone binding protein, Qcr8p. Hagerman RA, et al. Biochem Biophys Res Commun, 2006 May 26. PMID 16597436
  5. A region of the C-terminal part of the 11-kDa subunit of ubiquinol-cytochrome-c oxidoreductase of the yeast Saccharomyces cerevisiae contributes to the structure of the Qout reaction domain. Hemrika W, et al. Eur J Biochem, 1993 Aug 1. PMID 8394810

See all (100) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables quinol-cytochrome-c reductase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in aerobic respiration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular respiration IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitochondrial electron transport, ubiquinol to cytochrome c IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial electron transport, ubiquinol to cytochrome c IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitochondrial electron transport, ubiquinol to cytochrome c IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial electron transport, ubiquinol to cytochrome c IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane TAS
Traceable Author Statement
more info
  
located_in mitochondrion HDA PubMed 
part_of respiratory chain complex III IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of respiratory chain complex III IDA
Inferred from Direct Assay
more info
 PubMed 
part_of respiratory chain complex III IEA
Inferred from Electronic Annotation
more info
  
part_of respiratory chain complex III IPI
Inferred from Physical Interaction
more info
 PubMed 
Preferred Names
ubiquinol--cytochrome-c reductase subunit 8
NP_012369.1
  • Subunit 8 of ubiquinol cytochrome-c reductase (Complex III); Complex III is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    106434..106718
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181599.1 → NP_012369.1  TPA: ubiquinol--cytochrome-c reductase subunit 8

    See identical proteins and their annotated locations for NP_012369.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VW21, P08525
    UniProtKB/TrEMBL
    A0A0L8VMI9, A6ZQG6, B3LPV7, C7GRZ4, C8ZB53, G2WGK7, N1P3U7
    Conserved Domains (1) summary
    pfam02939
    Location:12 → 89
    UcrQ; UcrQ family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P08525.2

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