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CDC6 AAA family ATPase CDC6 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853244, updated on 11-Apr-2024

Summary

Gene symbol
CDC6
Gene description
AAA family ATPase CDC6
Primary source
SGD:S000003730
Locus tag
YJL194W
See related
AllianceGenome:SGD:S000003730
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables several functions, including DNA replication origin binding activity; nucleoside-triphosphatase activity; and purine ribonucleoside triphosphate binding activity. Involved in G1/S transition of mitotic cell cycle; pre-replicative complex assembly involved in nuclear cell cycle DNA replication; and regulation of DNA-dependent DNA replication initiation. Located in cytoplasm and nucleus. Part of DNA replication preinitiation complex and nuclear pre-replicative complex. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 5. Orthologous to human CDC6 (cell division cycle 6). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See CDC6 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (69338..70879)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene putative ubiquitin-specific protease UBP12 Neighboring gene fatty acid elongase ELO1 Neighboring gene uncharacterized protein Neighboring gene Sop4p

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA replication origin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA replication origin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables GTP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables chromatin binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables cyclin-dependent protein serine/threonine kinase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cyclin-dependent protein serine/threonine kinase inhibitor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of DNA replication preinitiation complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm HDA PubMed 
part_of nuclear pre-replicative complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus HDA PubMed 
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
AAA family ATPase CDC6
NP_012341.1
  • Essential ATP-binding protein required for DNA replication; component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association; dual role as a mitotic cyclin-dependent kinase inhibitor, that binds to and inhibits Cdc28p/Clb2p along with Sic1p, contributing to mitotic exit; homologous to S. pombe Cdc18p; relocalizes from nucleus to cytoplasm upon DNA replication stress; degraded in response to plasma membrane stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    69338..70879
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181627.1NP_012341.1  TPA: AAA family ATPase CDC6 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012341.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVZ7, P09119
    UniProtKB/TrEMBL
    A0A6L0Z1P4, A6ZQE2, C7GS16, C8ZB26, G2WGI3, N1P1K7
    Conserved Domains (1) summary
    COG1474
    Location:77508
    CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]