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ACO2 aconitate hydratase ACO2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853230, updated on 5-May-2019

Summary

Gene symbol
ACO2
Gene description
aconitate hydratase ACO2
Primary source
SGD:S000003736
Locus tag
YJL200C
Gene type
protein coding
RNA name
aconitate hydratase ACO2
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces

Genomic context

See ACO2 in Genome Data Viewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (56444..58813, complement)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Prp21p Neighboring gene Ecm25p Neighboring gene tRNA Neighboring gene Mbb1p

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
4 iron, 4 sulfur cluster binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
aconitate hydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
aconitate hydratase activity IEA
Inferred from Electronic Annotation
more info
 
aconitate hydratase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
lyase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
cellular amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
lysine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
lysine biosynthetic process via aminoadipic acid IEA
Inferred from Electronic Annotation
more info
 
tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion HDA PubMed 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
aconitate hydratase ACO2
NP_012335.1
  • Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    56444..58813 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181633.1NP_012335.1  TPA: aconitate hydratase ACO2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012335.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P39533
    Conserved Domains (3) summary
    TIGR01340
    Location:35782
    aconitase_mito; aconitate hydratase, mitochondrial
    cl00215
    Location:590734
    Aconitase_swivel; Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme ...
    cl00285
    Location:92506
    Aconitase; Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle
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