IMA1 oligo-1,6-glucosidase IMA1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: IMA1
Official Full Name: oligo-1,6-glucosidase IMA1
Primary source: SGD:S000003519
Locus tag: YGR287C
See related: AllianceGenome:SGD:S000003519; FungiDB:YGR287C; VEuPathDB:YGR287C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables oligo-1,6-glucosidase activity and sucrose alpha-glucosidase activity. Involved in disaccharide catabolic process. Located in mitochondrion. Human ortholog(s) of this gene implicated in cystinuria. Orthologous to human SLC3A1 (solute carrier family 3 member 1). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Genomic context

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See IMA1 in Genome Data Viewer

Location:: chromosome: VII

Exon count:: 1

Sequence:: Chromosome: VII; NC_001139.9 (1067222..1068991, complement)

Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results show that 2 amino acid residues appeared important in determining the substrate specificity of alpha-glucosidases.
Title: Steric hindrance by 2 amino acid residues determines the substrate specificity of isomaltase from Saccharomyces cerevisiae.
Discovery of a novel family of alpha-glucosidase IMA genes.
Title: Discovery of a novel family of alpha-glucosidase IMA genes in yeast Saccharomyces cerevisiae.
features of the isomaltase active site pocket prevent isomalto-oligosaccharides from binding to the active site effectively.
Title: Crystal structures of isomaltase from Saccharomyces cerevisiae and in complex with its competitive inhibitor maltose.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables alpha-1,4-glucosidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables alpha-amylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables alpha-glucosidase activity	IEA Inferred from Electronic Annotation more info
enables glucan 1,4-alpha-maltotriohydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on glycosyl bonds	IEA Inferred from Electronic Annotation more info
enables oligo-1,6-glucosidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables oligo-1,6-glucosidase activity	IDA Inferred from Direct Assay more info	PubMed
enables oligo-1,6-glucosidase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sucrose alpha-glucosidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables sucrose alpha-glucosidase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in disaccharide catabolic process	IEA Inferred from Electronic Annotation more info
involved_in disaccharide catabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in disaccharide catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maltose catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in maltose metabolic process	IEA Inferred from Electronic Annotation more info
involved_in sucrose catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: oligo-1,6-glucosidase IMA1

NP_011803.3

EC 3.2.1.10

Major isomaltase (alpha-1,6-glucosidase/alpha-methylglucosidase); required for isomaltose utilization; preferred specificity for isomaltose, alpha-methylglucoside, and palatinose, but also exhibits alpha-1,2 glucosidase activity on sucrose and kojibiose, and can cleave the 1,3-alpha linkage of nigerose and turanose and the alpha-1,5 linkage of leucrose in vitro; member of the IMA isomaltase family

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001139.9 Reference assembly

Range

1067222..1068991 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181416.3 → NP_011803.3 oligo-1,6-glucosidase IMA1

See identical proteins and their annotated locations for NP_011803.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VV64, P53051, Q76CZ0

UniProtKB/TrEMBL

B5VJN1, E1AFY6, N1P4E3

Conserved Domains (2) summary

cd11333
Location:16 → 503

AmyAc_SI_OligoGlu_DGase; Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins

cl02706
Location:514 → 585

Malt_amylase_C; Maltogenic Amylase, C-terminal domain