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ERV29 protein ERV29 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853201, updated on 8-Mar-2025

Summary

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Official Symbol
ERV29
Official Full Name
protein ERV29
Primary source
SGD:S000003516
Locus tag
YGR284C
See related
AllianceGenome:SGD:S000003516; FungiDB:YGR284C; VEuPathDB:YGR284C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables COPII receptor activity. Involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Located in COPII-coated ER to Golgi transport vesicle. Orthologous to human SURF4 (surfeit 4). [provided by Alliance of Genome Resources, Mar 2025]
Orthologs
all
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Genomic context

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See ERV29 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (1060658..1061590, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene glucan 1,3-beta-glucosidase Neighboring gene putative methyltransferase Neighboring gene zuotin Neighboring gene biotin synthase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Membrane topology of the endoplasmic reticulum to Golgi transport factor Erv29p. Foley DA, et al. Mol Membr Biol, 2007 Jul-Aug. PMID 17520482
  2. Role of Erv29p in collecting soluble secretory proteins into ER-derived transport vesicles. Belden WJ, et al. Science, 2001 Nov 16. PMID 11711675
  3. Sorting signals can direct receptor-mediated export of soluble proteins into COPII vesicles. Otte S, et al. Nat Cell Biol, 2004 Dec. PMID 15516922
  4. Surf4 (Erv29p) binds amino-terminal tripeptide motifs of soluble cargo proteins with different affinities, enabling prioritization of their exit from the endoplasmic reticulum. Yin Y, et al. PLoS Biol, 2018 Aug. PMID 30086131, Free PMC Article
  5. Sec16 function in ER export and autophagy is independent of its phosphorylation in Saccharomyces cerevisiae. Yorimitsu T, et al. Mol Biol Cell, 2020 Feb 1. PMID 31851588, Free PMC Article

See all (71) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Surf4 (or its yeast ortholog, Erv29p) binds amino-terminal tripeptide motifs of soluble cargo proteins with different affinities, enabling prioritization of their exit from the endoplasmic reticulum.
    Title: Surf4 (Erv29p) binds amino-terminal tripeptide motifs of soluble cargo proteins with different affinities, enabling prioritization of their exit from the endoplasmic reticulum.
  2. Erv29p contains four transmembrane domains with both termini exposed to the cytosol. Two luminal loops may contain a recognition site for hydrophobic export signals on soluble cargo
    Title: Membrane topology of the endoplasmic reticulum to Golgi transport factor Erv29p.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables COPII receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in COPII-coated ER to Golgi transport vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum HDA PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein ERV29
NP_011800.3
  • Protein localized to COPII-coated vesicles; involved in vesicle formation and incorporation of specific secretory cargo; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    1060658..1061590 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181413.3 → NP_011800.3  TPA: protein ERV29 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011800.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VV61, E9P8T4, P53337
    UniProtKB/TrEMBL
    A6ZUU0, B3LHW1, B5VJM8, C7GNF1, C8Z9H7, N1P2S5
    Conserved Domains (1) summary
    cl21527
    Location:48 → 310
    DoxX
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53337.1

Gene LinkOut

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