U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

APL6 Apl6p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853177, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
APL6
Official Full Name
Apl6p
Primary source
SGD:S000003493
Locus tag
YGR261C
See related
AllianceGenome:SGD:S000003493; FungiDB:YGR261C; VEuPathDB:YGR261C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
YKS5
Summary
Involved in Golgi to vacuole transport and protein targeting to vacuole. Located in cytosol. Part of AP-3 adaptor complex. Human ortholog(s) of this gene implicated in Hermansky-Pudlak syndrome (multiple); developmental and epileptic encephalopathy 48; interstitial lung disease (multiple); and neutropenia. Orthologous to several human genes including AP3B2 (adaptor related protein complex 3 subunit beta 2). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See APL6 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (1014321..1016750, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene ssDNA endodeoxyribonuclease RAD2 Neighboring gene Tna1p Neighboring gene serine/threonine protein kinase BUD32 Neighboring gene steryl deacetylase

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Identification of the yeast R-SNARE Nyv1p as a novel longin domain-containing protein. Wen W, et al. Mol Biol Cell, 2006 Oct. PMID 16855025, Free PMC Article
  2. Analysis of an 11.6 kb region from the right arm of chromosome VII of Saccharomyces cerevisiae between the RAD2 and the MES1 genes reveals the presence of three new genes. Clemente ML, et al. Yeast, 1997 Mar 15. PMID 9090059
  3. A genome-wide copper-sensitized screen identifies novel regulators of mitochondrial cytochrome c oxidase activity. Garza NM, et al. J Biol Chem, 2021 Jan-Jun. PMID 33662401, Free PMC Article
  4. Genetically encoded multimode reporter of adaptor complex 3 traffic in budding yeast. Plemel RL, et al. Traffic, 2021 Jan. PMID 33225520, Free PMC Article
  5. The AP-3 adaptor complex is essential for cargo-selective transport to the yeast vacuole. Cowles CR, et al. Cell, 1997 Oct 3. PMID 9335339

See all (71) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in Golgi to vacuole transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein targeting to vacuole IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of AP-3 adaptor complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in clathrin-coated vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of membrane coat IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Apl6p
NP_011777.3
  • Beta3-like subunit of the yeast AP-3 complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; exists in both cytosolic and peripherally associated membrane-bound pools

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    1014321..1016750 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181390.3 → NP_011777.3  TPA: Apl6p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011777.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VV40, P46682
    UniProtKB/TrEMBL
    B3LHY1, B5VJK3, C7GNH1, C8Z9F3, N1P9Z4
    Conserved Domains (2) summary
    COG5096
    Location:6 → 770
    COG5096; Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport]
    sd00044
    Location:119 → 146
    HEAT; HEAT repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P46682.2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools