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GCN5 histone acetyltransferase GCN5 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853167, updated on 2-Nov-2024

Summary

Official Symbol
GCN5
Official Full Name
histone acetyltransferase GCN5
Primary source
SGD:S000003484
Locus tag
YGR252W
See related
AllianceGenome:SGD:S000003484; FungiDB:YGR252W; VEuPathDB:YGR252W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
AAS104; ADA4; KAT2; SWI9
Summary
Enables N-acyltransferase activity; lysine-acetylated histone binding activity; and transcription coregulator activity. Involved in chromatin remodeling and positive regulation of transcription elongation by RNA polymerase II. Located in chromosome, centromeric region; cytosol; and nucleus. Part of ADA complex; SAGA complex; and SLIK (SAGA-like) complex. Orthologous to several human genes including KAT2A (lysine acetyltransferase 2A). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See GCN5 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (996869..998188)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Rie1p Neighboring gene Nop19p Neighboring gene proteasome core particle subunit alpha 5 Neighboring gene phosphopyruvate hydratase ENO1

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Component Evidence Code Pubs
part_of ADA complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of SAGA complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of SLIK (SAGA-like) complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromosome, centromeric region IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
part_of histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
histone acetyltransferase GCN5
NP_011768.1
  • Catalytic subunit of ADA and SAGA histone acetyltransferase complexes; modifies N-terminal lysines on histones H2B and H3; acetylates Rsc4p, a subunit of the RSC chromatin-remodeling complex, altering replication stress tolerance; relocalizes to the cytosol in response to hypoxia; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; greater involvement in repression of RNAPII-dependent transcription than in activation

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    996869..998188
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181381.1NP_011768.1  TPA: histone acetyltransferase GCN5 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011768.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VV32, Q03330, Q6B165
    UniProtKB/TrEMBL
    B3LHY8, B5VJJ4, C7GNH8, C8Z9E4, G2WEX8, N1P4F7
    Conserved Domains (1) summary
    COG5076
    Location:77439
    COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]