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SOL4 6-phosphogluconolactonase SOL4 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853163, updated on 9-Dec-2024

Summary

Official Symbol
SOL4
Official Full Name
6-phosphogluconolactonase SOL4
Primary source
SGD:S000003480
Locus tag
YGR248W
See related
AllianceGenome:SGD:S000003480; FungiDB:YGR248W; VEuPathDB:YGR248W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables 6-phosphogluconolactonase activity. Predicted to be involved in pentose-phosphate shunt, oxidative branch. Located in cytosol. Orthologous to human PGLS (6-phosphogluconolactonase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

See SOL4 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (985972..986739)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene transcription factor TFIIIB subunit BRF1 Neighboring gene 2',3'-cyclic-nucleotide 3'-phosphodiesterase Neighboring gene Mga1p Neighboring gene Rie1p

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 6-phosphogluconolactonase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables 6-phosphogluconolactonase activity IEA
Inferred from Electronic Annotation
more info
 
enables 6-phosphogluconolactonase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in pentose-phosphate shunt IEA
Inferred from Electronic Annotation
more info
 
involved_in pentose-phosphate shunt, oxidative branch IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in pentose-phosphate shunt, oxidative branch IC
Inferred by Curator
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus HDA PubMed 

General protein information

Preferred Names
6-phosphogluconolactonase SOL4
NP_011764.3
  • 6-phosphogluconolactonase; protein abundance increases in response to DNA replication stress; SOL4 has a paralog, SOL3, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    985972..986739
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181377.3NP_011764.3  TPA: 6-phosphogluconolactonase SOL4 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011764.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VV28, P53315
    UniProtKB/TrEMBL
    B3LHZ2, B5VJI9, C7GNI1, G2WEX4, N1P673
    Conserved Domains (1) summary
    COG0363
    Location:2252
    NagB; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]