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CPD1 2',3'-cyclic-nucleotide 3'-phosphodiesterase [ Saccharomyces cerevisiae S288C ]

Gene ID: 853162, updated on 6-Jul-2026
Official Symbol
CPD1
Official Full Name
2',3'-cyclic-nucleotide 3'-phosphodiesterase
Primary source
SGD:S000003479
Locus tag
YGR247W
See related
AllianceGenome:SGD:S000003479; FungiDB:YGR247W; VEuPathDB:YGR247W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity. Involved in cyclic nucleotide metabolic process. Located in clathrin-coated vesicle. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See CPD1 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (984966..985685)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Sda1p Neighboring gene transcription factor TFIIIB subunit BRF1 Neighboring gene 6-phosphogluconolactonase SOL4 Neighboring gene Mga1p

Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Characterization of the Saccharomyces cerevisiae cyclic nucleotide phosphodiesterase involved in the metabolism of ADP-ribose 1",2"-cyclic phosphate. Nasr F, et al. Nucleic Acids Res, 2000 Apr 15. PMID 10734185, Free PMC Article
  2. tRNA splicing in yeast and wheat germ. A cyclic phosphodiesterase implicated in the metabolism of ADP-ribose 1",2"-cyclic phosphate. Culver GM, et al. J Biol Chem, 1994 Oct 7. PMID 7929175
  3. Biophysical characterization of cyclic nucleotide phosphodiesterases. Hofmann A, et al. Biochem Biophys Res Commun, 2002 Mar 8. PMID 11866446
  4. A biochemical genomics approach for identifying genes by the activity of their products. Martzen MR, et al. Science, 1999 Nov 5. PMID 10550052
  5. A highly specific phosphatase that acts on ADP-ribose 1''-phosphate, a metabolite of tRNA splicing in Saccharomyces cerevisiae. Shull NP, et al. Nucleic Acids Res, 2005. PMID 15684411, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity EXP
Inferred from Experiment
more info
 PubMed 
enables 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
  
enables 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables cyclic-nucleotide phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cyclic nucleotide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cyclic nucleotide metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in clathrin-coated vesicle HDA PubMed 
Preferred Names
2',3'-cyclic-nucleotide 3'-phosphodiesterase
NP_011763.1
  • Cyclic nucleotide phosphodiesterase; hydrolyzes ADP-ribose 1'', 2''-cyclic phosphate to ADP-ribose 1''-phosphate; may have a role in tRNA splicing; no detectable phenotype is conferred by null mutation or by overexpression; protein abundance increases in response to DNA replication stress

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    984966..985685
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181376.1 → NP_011763.1  2',3'-cyclic-nucleotide 3'-phosphodiesterase

    See identical proteins and their annotated locations for NP_011763.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VV27, P53314
    UniProtKB/TrEMBL
    B3LHZ3
    Conserved Domains (1) summary
    pfam07823
    Location:1 → 239
    CPDase; Cyclic phosphodiesterase-like protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53314.1

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