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PFK1 6-phosphofructokinase subunit alpha [ Saccharomyces cerevisiae S288C ]

Gene ID: 853155, updated on 14-Nov-2024

Summary

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Official Symbol
PFK1
Official Full Name
6-phosphofructokinase subunit alpha
Primary source
SGD:S000003472
Locus tag
YGR240C
See related
AllianceGenome:SGD:S000003472; FungiDB:YGR240C; VEuPathDB:YGR240C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Contributes to 6-phosphofructokinase activity. Involved in glycolytic process and regulation of intracellular pH. Located in mitochondrion. Part of 6-phosphofructokinase complex. Used to study glycogen storage disease. Human ortholog(s) of this gene implicated in glycogen storage disease VII. Orthologous to human PFKL (phosphofructokinase, liver type); PFKM (phosphofructokinase, muscle); and PFKP (phosphofructokinase, platelet). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See PFK1 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (970771..973734, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Kel2p Neighboring gene Pex21p Neighboring gene uncharacterized protein Neighboring gene Yap1802p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Weak organic acid treatment causes a trehalose accumulation in low-pH cultures of Saccharomyces cerevisiae, not displayed by the more preservative-resistant Zygosaccharomyces bailii. Cheng L, et al. FEMS Microbiol Lett, 1999 Jan 1. PMID 9919656
  2. The first three-dimensional structure of phosphofructokinase from Saccharomyces cerevisiae determined by electron microscopy of single particles. Ruiz T, et al. J Struct Biol, 2001 Dec. PMID 12051897
  3. The structure of the ATP-bound state of S. cerevisiae phosphofructokinase determined by cryo-electron microscopy. Bárcena M, et al. J Struct Biol, 2007 Jul. PMID 17493831, Free PMC Article
  4. Glycolytic oscillations and waves in an open spatial reactor: Impact of feedback regulation of phosphofructokinase. Bagyan S, et al. Biophys Chem, 2005 Jun 1. PMID 15911083
  5. Construction and physiological characterization of mutants disrupted in the phosphofructokinase genes of Saccharomyces cerevisiae. Heinisch J. Curr Genet, 1986. PMID 2965996

See all (180) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PCK1 Deficiency Shortens the Replicative Lifespan of Saccharomyces cerevisiae through Upregulation of PFK1.
    Title: PCK1 Deficiency Shortens the Replicative Lifespan of Saccharomyces cerevisiae through Upregulation of PFK1.
  2. Regulation of Vacuolar H+-ATPase (V-ATPase) Reassembly by Glycolysis Flow in 6-Phosphofructo-1-kinase (PFK-1)-deficient Yeast Cells.
    Title: Regulation of Vacuolar H+-ATPase (V-ATPase) Reassembly by Glycolysis Flow in 6-Phosphofructo-1-kinase (PFK-1)-deficient Yeast Cells.
  3. stability and function of the metabolon composed of H+ATPase and glycolytic components can be compromised by either loss of required PFK-1 binding (G820R) or loss of pump protein (R807Q)
    Title: Human H+ATPase a4 subunit mutations causing renal tubular acidosis reveal a role for interaction with phosphofructokinase-1.
  4. Pfk1 underwent a large conformational change upon Mg-ATP binding arising from a reorientation of the alpha- and beta-subunits in the dimers.
    Title: The structure of the ATP-bound state of S. cerevisiae phosphofructokinase determined by cryo-electron microscopy.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 6-phosphofructokinase activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to 6-phosphofructokinase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
contributes_to 6-phosphofructokinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables fructose-6-phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in canonical glycolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fructose 1,6-bisphosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fructose 6-phosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fructose 6-phosphate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycolytic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glycolytic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycolytic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in glycolytic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of intracellular pH IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of 6-phosphofructokinase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of 6-phosphofructokinase complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
6-phosphofructokinase subunit alpha
NP_011756.1
  • Alpha subunit of heterooctameric phosphofructokinase; involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    970771..973734 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181369.1 → NP_011756.1  TPA: 6-phosphofructokinase subunit alpha [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011756.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VV20, P16861
    UniProtKB/TrEMBL
    A6ZUP8, B3LI00, C7GNI9, C8Z9D1, G2WEW6, N1P2M1
    Conserved Domains (2) summary
    TIGR02478
    Location:206 → 972
    6PF1K_euk; 6-phosphofructokinase, eukaryotic type
    pfam18468
    Location:8 → 101
    Pfk_N; Phosphofructokinase N-terminal domain yeast
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P16861.1

Gene LinkOut

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