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PEX21 Pex21p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853154, updated on 3-Jun-2026
Official Symbol
PEX21
Official Full Name
Pex21p
Primary source
SGD:S000003471
Locus tag
YGR239C
See related
AllianceGenome:SGD:S000003471; FungiDB:YGR239C; VEuPathDB:YGR239C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in protein import into peroxisome matrix. Located in cytosol and peroxisome. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See PEX21 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (969187..970053, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Kel2p Neighboring gene 6-phosphofructokinase subunit alpha Neighboring gene uncharacterized protein

Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The proximal region of a noncatalytic eukaryotic seryl-tRNA synthetase extension is required for protein stability in vitro and in vivo. Mocibob M, et al. Arch Biochem Biophys, 2008 Feb 15. PMID 18067851
  2. Peroxin Pex21p interacts with the C-terminal noncatalytic domain of yeast seryl-tRNA synthetase and forms a specific ternary complex with tRNA(Ser). Godinic V, et al. FEBS J, 2007 Jun. PMID 17451428
  3. Identifying Pex21p as a protein that specifically interacts with yeast seryl-tRNA synthetase. Rocak S, et al. FEMS Microbiol Lett, 2002 Aug 27. PMID 12204379
  4. Yarrowia lipolytica Pex20p, Saccharomyces cerevisiae Pex18p/Pex21p and mammalian Pex5pL fulfil a common function in the early steps of the peroxisomal PTS2 import pathway. Einwächter H, et al. EMBO Rep, 2001 Nov. PMID 11606420, Free PMC Article
  5. Crystal structure of peroxisomal targeting signal-2 bound to its receptor complex Pex7p-Pex21p. Pan D, et al. Nat Struct Mol Biol, 2013 Aug. PMID 23812376

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein carrier activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein import into peroxisome matrix IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein import into peroxisome matrix IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein import into peroxisome matrix IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein import into peroxisome matrix NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of cargo receptor complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytoplasm HDA PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
Pex21p
NP_011755.3
  • Peroxin required for peroxisomal matrix protein targeting; acts on proteins containing the PTS2 targeting sequence; interacts with Pex7p; constitutively expressed; partially redundant with Pex18p; required for import of the Gpd1p-Pnc1p heterodimer in which only Gpd1p has a peroxisomal targeting signal; relative distribution to cytoplasmic foci increases upon DNA replication stress

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    969187..970053 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181368.3 → NP_011755.3  Pex21p

    See identical proteins and their annotated locations for NP_011755.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VV19, O11855, P50091, Q6Q597
    UniProtKB/TrEMBL
    A6ZUP7, B3LI01, B5VJH9, C7GNJ0, C8Z9D0, N1P422
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P50091.1

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