Format

Send to:

Choose Destination

YHB1 flavohemoglobin [ Saccharomyces cerevisiae S288C ]

Gene ID: 853149, updated on 25-Jan-2022

Summary

Gene symbol
YHB1
Gene description
flavohemoglobin
Primary source
SGD:S000003466
Locus tag
YGR234W
See related
AllianceGenome:SGD:S000003466
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
YHB4
Summary
Enables nitric oxide reductase activity. Involved in cellular response to misfolded protein; cellular response to oxidative stress; and cellular response to reactive nitrogen species. Located in cytosol and mitochondrial matrix. Orthologous to human NGB (neuroglobin). [provided by Alliance of Genome Resources, Nov 2021]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See YHB1 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (959904..961103)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Nas6p Neighboring gene Pho81p Neighboring gene Mic26p Neighboring gene Spg1p

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables FAD binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables FAD binding IEA
Inferred from Electronic Annotation
more info
 
enables heme binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nitric oxide dioxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nitric oxide dioxygenase activity IEA
Inferred from Electronic Annotation
more info
 
enables nitric oxide reductase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxygen binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cellular response to misfolded protein IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to nitrosative stress IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to oxidative stress IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to reactive nitrogen species IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nitric oxide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to nitrosative stress IEA
Inferred from Electronic Annotation
more info
 
involved_in response to toxic substance IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
flavohemoglobin
NP_011750.1
  • Nitric oxide oxidoreductase; flavohemoglobin that plays role in oxidative and nitrosative stress responses; protects against nitration of cellular targets and against cell growth inhibition under aerobic or anaerobic conditions; yeast flavohemoglobin Yhb1p and human homolog neuroglobin NGB protect cells against alpha-synuclein cytotoxicity and aggregate formation; protein increases in abundance, relocalizes from nucleus to cytoplasmic foci upon DNA replication stress

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    959904..961103
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181363.1NP_011750.1  TPA: flavohemoglobin [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011750.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P39676
    Conserved Domains (1) summary
    PRK13289
    Location:1392
    PRK13289; NO-inducible flavohemoprotein
Support Center