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PHO81 Pho81p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853148, updated on 24-Jan-2026
Official Symbol
PHO81
Official Full Name
Pho81p
Primary source
SGD:S000003465
Locus tag
YGR233C
See related
AllianceGenome:SGD:S000003465; FungiDB:YGR233C; VEuPathDB:YGR233C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
VAC6
Summary
Enables cyclin-dependent protein serine/threonine kinase inhibitor activity. Involved in cellular response to phosphate starvation and phosphate-containing compound metabolic process. Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See PHO81 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (954674..958210, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene prohibitin subunit PHB2 Neighboring gene Nas6p Neighboring gene flavohemoglobin Neighboring gene Mic26p

Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Negative transcriptional regulation of PH081 expression in Saccharomyces cerevisiae. Creasy CL, et al. Gene, 1996 Feb 2. PMID 8626060
  2. A metabolite sensor subunit of the Atg1/ULK complex regulates selective autophagy. Gross AS, et al. Nat Cell Biol, 2024 Mar. PMID 38316984, Free PMC Article
  3. Inositol pyrophosphate dynamics reveals control of the yeast phosphate starvation program through 1,5-IP(8) and the SPX domain of Pho81. Chabert V, et al. Elife, 2023 Sep 20. PMID 37728314, Free PMC Article
  4. Functional Domains of the Regulatory Factor PHO81 of Saccharomyces cerevisiae. Wu JS, et al. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai), 1996. PMID 12232612
  5. Functional Analysis of the Upstream Sequence of PHO81 Gene of Saccharomyces cerevisiae. Xia ZX, et al. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai), 1999. PMID 12142922

See all (102) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inositol pyrophosphate dynamics reveals control of the yeast phosphate starvation program through 1,5-IP8 and the SPX domain of Pho81.
    Title: Inositol pyrophosphate dynamics reveals control of the yeast phosphate starvation program through 1,5-IP(8) and the SPX domain of Pho81.
  2. Full-length Pho81 is required to control trehalose metabolism and the PDS targets in Saccharomyces.
    Title: The minimum domain of Pho81 is not sufficient to control the Pho85-Rim15 effector branch involved in phosphate starvation-induced stress responses.
  3. myo-d-inositol heptakisphosphate is necessary for Pho81-dependent inhibition of Pho80-Pho85 in vitro; fndings reveal regulation of a cyclin-CDK complex by a metabolite & suggest that a complex metabolic network mediates signaling of phosphate availability
    Title: Regulation of a cyclin-CDK-CDK inhibitor complex by inositol pyrophosphates.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase inhibitor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables phosphoric diester hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to phosphate starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within pexophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphate-containing compound metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol HDA PubMed 
located_in nucleus HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
Pho81p
NP_011749.3
  • Cyclin-dependent kinase (CDK) inhibitor; regulates Pho80p-Pho85p and Pcl7p-Pho85p cyclin-CDK complexes in response to phosphate levels; inhibitory activity for Pho80p-Pho85p requires myo-D-inositol heptakisphosphate (IP7) generated by Vip1p; senses phosphate metabolites via the SPX domain to regulate pexophagy in response to phosphate starvation; relative distribution to the nucleus increases upon DNA replication stress

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    954674..958210 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181362.3 → NP_011749.3  Pho81p

    See identical proteins and their annotated locations for NP_011749.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VV13, P17442, Q06887
    UniProtKB/TrEMBL
    G2WEV9, N1P9Y8
    Conserved Domains (5) summary
    PHA02875
    Location:466 → 650
    PHA02875; ankyrin repeat protein; Provisional
    cd08578
    Location:875 → 1172
    GDPD_NUC-2_fungi; Putative glycerophosphodiester phosphodiesterase domain of ankyrin repeat protein NUC-2 and similar proteins
    cd14483
    Location:2 → 159
    SPX_PHO81_NUC-2_like; SPX domain of Pho81, NUC-2, and similar proteins
    sd00045
    Location:561 → 588
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:561 → 647
    Ank_2; Ankyrin repeats (3 copies)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P17442.2

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