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CCH1 Cch1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853131, updated on 8-Feb-2025

Summary

Official Symbol
CCH1
Official Full Name
Cch1p
Primary source
SGD:S000003449
Locus tag
YGR217W
See related
AllianceGenome:SGD:S000003449; FungiDB:YGR217W; VEuPathDB:YGR217W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables calcium channel activity. Involved in calcium ion transport. Located in plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including brain disease (multiple); congenital myopathy (multiple); heart conduction disease (multiple); intrinsic cardiomyopathy (multiple); and neuropathy (multiple). Orthologous to several human genes including CACNA1C (calcium voltage-gated channel subunit alpha1 C); CACNA1D (calcium voltage-gated channel subunit alpha1 D); and CACNA1F (calcium voltage-gated channel subunit alpha1 F). [provided by Alliance of Genome Resources, Feb 2025]
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Genomic context

See CCH1 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (924696..930815)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene mitochondrial 37S ribosomal protein RSM27 Neighboring gene phosphatidylinositol N-acetylglucosaminyltransferase Neighboring gene tRNA-Gly Neighboring gene exportin CRM1

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables calcium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium channel activity IEA
Inferred from Electronic Annotation
more info
 
enables calcium channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables high voltage-gated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
 
enables voltage-gated calcium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
involved_in calcium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in calcium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in calcium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
part_of voltage-gated calcium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
Cch1p
NP_011733.3
  • Voltage-gated high-affinity calcium channel; involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and partially co-localizes with Mid1p; however, evidence suggests CCH1 is not required for Mid1p function

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    924696..930815
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181346.3NP_011733.3  TPA: Cch1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011733.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VV00, P50077
    UniProtKB/TrEMBL
    C7GTX9, C8Z9A9, N1P4B6
    Conserved Domains (1) summary
    pfam00520
    Location:12101480
    Ion_trans; Ion transport protein