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PPIL4 peptidylprolyl isomerase like 4 [ Homo sapiens (human) ]

Gene ID: 85313, updated on 5-May-2024

Summary

Official Symbol
PPIL4provided by HGNC
Official Full Name
peptidylprolyl isomerase like 4provided by HGNC
Primary source
HGNC:HGNC:15702
See related
Ensembl:ENSG00000131013 MIM:607609; AllianceGenome:HGNC:15702
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HDCME13P
Summary
This gene is a member of the cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 15.0), gall bladder (RPKM 11.6) and 25 other tissues See more
Orthologs
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Genomic context

Location:
6q25.1
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (149504495..149546043, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (150704210..150745755, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (149825631..149867179, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:149772303-149772854 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:149772855-149773406 Neighboring gene zinc finger CCCH-type containing 12D Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25255 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25256 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:149794343-149794528 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17661 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:149802875-149803730 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25258 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:149805477-149806341 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25260 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:149817836-149818336 Neighboring gene coiled-coil domain containing 59 pseudogene Neighboring gene RNA, U7 small nuclear 3 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25262 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:149868072-149868748 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17662 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25263 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17663 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25264 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25265 Neighboring gene glycosylated integral membrane protein 1 Neighboring gene ribosomal protein S18 pseudogene 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
peptidyl-prolyl cis-trans isomerase-like 4
Names
PPIase
cyclophilin-like protein PPIL4
cyclophilin-type peptidyl-prolyl cis-trans isomerase
peptidylprolyl isomerase (cyclophilin)-like 4
rotamase PPIL4
serologically defined breast cancer antigen NY-BR-18
NP_624311.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_139126.4NP_624311.1  peptidyl-prolyl cis-trans isomerase-like 4

    See identical proteins and their annotated locations for NP_624311.1

    Status: REVIEWED

    Source sequence(s)
    AF357880, AK315388, AL357619
    Consensus CDS
    CCDS34550.1
    UniProtKB/Swiss-Prot
    B2RD34, Q7Z3Q5, Q8WUA2
    UniProtKB/TrEMBL
    Q6P392
    Related
    ENSP00000253329.2, ENST00000253329.3
    Conserved Domains (2) summary
    cd01921
    Location:4161
    cyclophilin_RRM; cyclophilin_RRM: cyclophilin-type peptidylprolyl cis- trans isomerase domain occuring with a C-terminal RNA recognition motif domain (RRM). This subfamily of the cyclophilin domain family contains a number of eukaryotic cyclophilins having the RRM domain ...
    cd12235
    Location:237319
    RRM_PPIL4; RNA recognition motif in peptidyl-prolyl cis-trans isomerase-like 4 (PPIase) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    149504495..149546043 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    150704210..150745755 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)