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ADE3 trifunctional formate-tetrahydrofolate ligase/methenyltetrahydrofolate cyclohydrolase/methylenetetrahydrofolate dehydrogenase ADE3 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853118, updated on 5-May-2019

Summary

Gene symbol
ADE3
Gene description
trifunctional formate-tetrahydrofolate ligase/methenyltetrahydrofolate cyclohydrolase/methylenetetrahydrofolate dehydrogenase ADE3
Primary source
SGD:S000003436
Locus tag
YGR204W
Gene type
protein coding
RNA name
trifunctional formate-tetrahydrofolate ligase/methenyltetrahydrofolate cyclohydrolase/methylenetetrahydrofolate dehydrogenase ADE3
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces

Genomic context

See ADE3 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (905934..908774)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene choline-phosphate cytidylyltransferase Neighboring gene phosphatase YCH1 Neighboring gene hypothetical protein Neighboring gene putative ATP-dependent kinase

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the ADE3 gene: The ADE3 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.

Gene Ontology Provided by GO

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
catalytic activity IEA
Inferred from Electronic Annotation
more info
 
formate-tetrahydrofolate ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
formate-tetrahydrofolate ligase activity IEA
Inferred from Electronic Annotation
more info
 
formate-tetrahydrofolate ligase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
ligase activity IEA
Inferred from Electronic Annotation
more info
 
methenyltetrahydrofolate cyclohydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
methenyltetrahydrofolate cyclohydrolase activity IEA
Inferred from Electronic Annotation
more info
 
methenyltetrahydrofolate cyclohydrolase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
methylenetetrahydrofolate dehydrogenase (NADP+) activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
methylenetetrahydrofolate dehydrogenase (NADP+) activity IEA
Inferred from Electronic Annotation
more info
 
methylenetetrahydrofolate dehydrogenase (NADP+) activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
10-formyltetrahydrofolate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
folic acid-containing compound metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
histidine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
metabolic process IEA
Inferred from Electronic Annotation
more info
 
methionine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
one-carbon metabolic process IEA
Inferred from Electronic Annotation
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
purine nucleobase biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
purine nucleobase biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
purine nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
tetrahydrofolate interconversion IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm HDA PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus HDA PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
trifunctional formate-tetrahydrofolate ligase/methenyltetrahydrofolate cyclohydrolase/methylenetetrahydrofolate dehydrogenase ADE3
NP_011720.3
  • Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase; involved in single carbon metabolism and required for biosynthesis of purines, thymidylate, methionine, and histidine; null mutation causes auxotrophy for adenine and histidine

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    905934..908774
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181333.3NP_011720.3  TPA: trifunctional formate-tetrahydrofolate ligase/methenyltetrahydrofolate cyclohydrolase/methylenetetrahydrofolate dehydrogenase ADE3 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011720.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P07245
    Conserved Domains (4) summary
    cd01080
    Location:118297
    NAD_bind_m-THF_DH_Cyclohyd; NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
    COG0190
    Location:4303
    FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]
    pfam00763
    Location:5122
    THF_DHG_CYH; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
    pfam01268
    Location:322946
    FTHFS; Formate--tetrahydrofolate ligase
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