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SNG1 Sng1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853111, updated on 3-Dec-2023

Summary

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Gene symbol
SNG1
Gene description
Sng1p
Primary source
SGD:S000003429
Locus tag
YGR197C
See related
AllianceGenome:SGD:S000003429
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in nucleobase-containing compound transport; regulation of fungal-type cell wall organization; and regulation of phospholipid translocation. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (892497..894140, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene exosome non-catalytic core subunit SKI6 Neighboring gene Fyv8p Neighboring gene Ypp1p Neighboring gene dolichyl-phosphate-mannose-protein mannosyltransferase PMT6

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. SNG1--a new gene involved in nitrosoguanidine resistance in Saccharomyces cerevisiae. Grey M, et al. Mutat Res, 1995 Apr. PMID 7753113
  2. Genome-wide screening of Saccharomyces cerevisiae genes regulated by vanillin. Park EH, et al. J Microbiol Biotechnol, 2015 Jan. PMID 25269814
  3. Sng1 associates with Nce102 to regulate the yeast Pkh-Ypk signalling module in response to sphingolipid status. García-Marqués S, et al. Biochim Biophys Acta, 2016 Jun. PMID 27033517
  4. Overexpression of SNG1 causes 6-azauracil resistance in Saccharomyces cerevisiae. García-López MC, et al. Curr Genet, 2010 Jun. PMID 20424846
  5. New insights into the pleiotropic drug resistance network from genome-wide characterization of the YRR1 transcription factor regulation system. Le Crom S, et al. Mol Cell Biol, 2002 Apr. PMID 11909958, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data indicate that mutant nce102 sng1 cells show features of impaired Pkh/Ypk signalling, including increased reactive oxygen species accumulation.
    Title: Sng1 associates with Nce102 to regulate the yeast Pkh-Ypk signalling module in response to sphingolipid status.
  2. They have identified SNG1 as a multicopy suppressor of the 6AU(S) growth defect caused by the S. cerevisiae rpb1 mutant.
    Title: Overexpression of SNG1 causes 6-azauracil resistance in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in nucleobase-containing compound transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of fungal-type cell wall organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of phospholipid translocation IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cell periphery HDA PubMed 
located_in fungal-type vacuole HDA PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Sng1p
NP_011713.1
  • Protein involved in resistance to nitrosoguanidine and 6-azauracil; expression is regulated by transcription factors involved in multidrug resistance; SNG1 has a paralog, YJR015W, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    892497..894140 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181326.1 → NP_011713.1  TPA: Sng1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011713.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUX9, P46950
    UniProtKB/TrEMBL
    A0A6A5PW76, A6ZUK7, B3LI40, N1P2I3
    Conserved Domains (1) summary
    pfam12051
    Location:112 → 497
    DUF3533; Protein of unknown function (DUF3533)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P46950.1

Gene LinkOut

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