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HIP1 histidine permease [ Saccharomyces cerevisiae S288C ]

Gene ID: 853104, updated on 6-Jul-2026
Official Symbol
HIP1
Official Full Name
histidine permease
Primary source
SGD:S000003423
Locus tag
YGR191W
See related
AllianceGenome:SGD:S000003423; FungiDB:YGR191W; VEuPathDB:YGR191W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables high-affinity L-histidine transmembrane transporter activity. Involved in histidine transport and manganese ion transport. Located in plasma membrane. Orthologous to human SLC7A4 (solute carrier family 7 member 4). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See HIP1 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (880420..882231)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene transglycosylase Neighboring gene tRNA-Trp Neighboring gene glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH3 Neighboring gene Pdx1p

Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The histidine permease gene (HIP1) of Saccharomyces cerevisiae. Tanaka J, et al. Gene, 1985. PMID 3905514
  2. Involvement of histidine permease (Hip1p) in manganese transport in Saccharomyces cerevisiae. Farcasanu IC, et al. Mol Gen Genet, 1998 Sep. PMID 9790586
  3. [Ubiquitination regulation of histidine transporter Hip1p on histidine utilization in Saccharomyces cerevisiae]. Zhang P, et al. Wei Sheng Wu Xue Bao, 2016 Oct 4. PMID 29741343
  4. Regulation of histidine uptake by specific feedback inhibition of two histidine permeases in Saccharomyces cerevisiae. Crabeel M, et al. Eur J Biochem, 1970 May 1. PMID 5447432
  5. The complete sequence of a 9037 bp DNA fragment of the right arm of Saccharomyces cerevisiae chromosome VII. Arroyo J, et al. Yeast, 1995 May. PMID 7645350

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables high-affinity L-histidine transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-histidine transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in amino acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in amino acid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in histidine transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in manganese ion transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell periphery HDA PubMed 
located_in endoplasmic reticulum HDA PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Preferred Names
histidine permease
NP_011707.1
  • High-affinity histidine permease; also involved in the transport of manganese ions

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    880420..882231
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181320.1 → NP_011707.1  histidine permease

    See identical proteins and their annotated locations for NP_011707.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUX3, P06775
    Conserved Domains (1) summary
    TIGR00913
    Location:88 → 567
    2A0310; amino acid permease (yeast)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P06775.2

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