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HGH1 Hgh1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853099, updated on 3-May-2025
Official Symbol
HGH1
Official Full Name
Hgh1p
Primary source
SGD:S000003419
Locus tag
YGR187C
See related
AllianceGenome:SGD:S000003419; FungiDB:YGR187C; VEuPathDB:YGR187C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables translation elongation factor binding activity. Involved in chaperone-mediated protein folding. Located in cytoplasm and nucleus. Orthologous to human HGH1 (HGH1 homolog). [provided by Alliance of Genome Resources, May 2025]
Orthologs
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Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (870232..871416, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene tyrosine--tRNA ligase TYS1 Neighboring gene transcription factor IIF subunit TFG1 Neighboring gene protein kinase BUB1 Neighboring gene tRNA-Lys

Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. DNA sequence analysis of a 23,002 bp DNA fragment of the right arm of Saccharomyces cerevisiae chromosome VII. Arroyo J, et al. Yeast, 1997 Mar 30. PMID 9133739
  2. Hsp90 and cochaperones have two genetically distinct roles in regulating eEF2 function. Fulton MD, et al. PLoS Genet, 2024 Dec. PMID 39652595, Free PMC Article
  3. The Princeton Protein Orthology Database (P-POD): a comparative genomics analysis tool for biologists. Heinicke S, et al. PLoS One, 2007 Aug 22. PMID 17712414, Free PMC Article
  4. The deletion of six ORFs of unknown function from Saccharomyces cerevisiae chromosome VII reveals two essential genes: YGR195w and YGR198w. Rodriguez-Peña JM, et al. Yeast, 1998 Jun 30. PMID 9818723
  5. The Co-chaperone Cns1 and the Recruiter Protein Hgh1 Link Hsp90 to Translation Elongation via Chaperoning Elongation Factor 2. Schopf FH, et al. Mol Cell, 2019 Apr 4. PMID 30876805

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables translation elongation factor binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in chaperone-mediated protein folding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in nucleus HDA PubMed 
Preferred Names
Hgh1p
NP_011703.3
  • Chaperone protein for translation factor eEF2; involved in biogenesis of eukaryotic Elongation Factor 2 (Eft1p, Eft2p); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; similar to mammalian BRP16 (Brain protein 16); relative distribution to the nucleus increases upon DNA replication stress

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    870232..871416 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181316.3 → NP_011703.3  TPA: Hgh1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011703.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUX0, P48362
    UniProtKB/TrEMBL
    A6ZUJ8, B3LI48, B5VJC9, C7GVV4, C8Z980, G2WER6, N1P3W7
    Conserved Domains (2) summary
    pfam04063
    Location:99 → 301
    DUF383; Domain of unknown function (DUF383)
    pfam04064
    Location:306 → 360
    DUF384; Domain of unknown function (DUF384)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P48362.2

Gene LinkOut

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