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TRS65 Trs65p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853076, updated on 10-Feb-2026
Official Symbol
TRS65
Official Full Name
Trs65p
Primary source
SGD:S000003398
Locus tag
YGR166W
See related
AllianceGenome:SGD:S000003398; FungiDB:YGR166W; VEuPathDB:YGR166W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
KRE11
Summary
Contributes to guanyl-nucleotide exchange factor activity. Involved in intra-Golgi vesicle-mediated transport and protein-containing complex assembly. Located in trans-Golgi network. Part of TRAPPII protein complex. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See TRS65 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (830515..832197)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene tRNA-Arg Neighboring gene uncharacterized protein Neighboring gene mitochondrial 37S ribosomal protein mS45 MRPS35 Neighboring gene clathrin light chain CLC1 Neighboring gene Pex35p

Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. PROPHECY--a yeast phenome database, update 2006. Fernandez-Ricaud L, et al. Nucleic Acids Res, 2007 Jan. PMID 17148481, Free PMC Article
  2. SKN1 and KRE6 define a pair of functional homologs encoding putative membrane proteins involved in beta-glucan synthesis. Roemer T, et al. Mol Cell Biol, 1993 Jul. PMID 8321211, Free PMC Article
  3. Conservation of the TRAPPII-specific subunits of a Ypt/Rab exchanger complex. Cox R, et al. BMC Evol Biol, 2007 Feb 2. PMID 17274825, Free PMC Article
  4. The yeast KRE9 gene encodes an O glycoprotein involved in cell surface beta-glucan assembly. Brown JL, et al. Mol Cell Biol, 1993 Oct. PMID 8413233, Free PMC Article
  5. A mutational analysis of killer toxin resistance in Saccharomyces cerevisiae identifies new genes involved in cell wall (1-->6)-beta-glucan synthesis. Brown JL, et al. Genetics, 1993 Apr. PMID 8462845, Free PMC Article

See all (65) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Here we demonstrate that Trs65p directly binds to the C-terminus of the Arf1p exchange factor Gea2p and provide in vivo evidence that this interaction is physiologically relevant
    Title: Trs65p, a subunit of the Ypt1p GEF TRAPPII, interacts with the Arf1p exchange factor Gea2p to facilitate COPI-mediated vesicle traffic.
  2. These results show that Trs65 plays a role in the Ypt guanine nucleotide exchanger activity of TRAPP II in concert with the two other TRAPP II-specific subunits.
    Title: The role of Trs65 in the Ypt/Rab guanine nucleotide exchange factor function of the TRAPP II complex.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to guanyl-nucleotide exchange factor activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in beta-glucan biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cell wall organization IEA
Inferred from Electronic Annotation
more info
  
involved_in intra-Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intra-Golgi vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
involved_in intra-Golgi vesicle-mediated transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in intra-Golgi vesicle-mediated transport IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in intra-Golgi vesicle-mediated transport NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in protein-containing complex assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in retrograde transport, endosome to Golgi NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
part_of TRAPPII protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of TRAPPII protein complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of TRAPPII protein complex IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
Trs65p
NP_011682.1
  • Component of transport protein particle (TRAPP) complex II; TRAPPII is a multimeric guanine nucleotide-exchange factor for the GTPase Ypt1p, regulating intra-Golgi and endosome-Golgi traffic; role in cell wall beta-glucan biosynthesis and the stress response

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    830515..832197
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181295.1 → NP_011682.1  Trs65p

    See identical proteins and their annotated locations for NP_011682.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUU9, P32893
    UniProtKB/TrEMBL
    A6ZUH6, B3LI65, C7GQ73, C8Z961, N1P5Z9
    Conserved Domains (1) summary
    pfam12735
    Location:257 → 559
    Trs65; TRAPP trafficking subunit Trs65
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32893.1

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