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TIF4631 translation initiation factor eIF4G [ Saccharomyces cerevisiae S288C ]

Gene ID: 853071, updated on 3-Jun-2026
Official Symbol
TIF4631
Official Full Name
translation initiation factor eIF4G
Primary source
SGD:S000003394
Locus tag
YGR162W
See related
AllianceGenome:SGD:S000003394; FungiDB:YGR162W; VEuPathDB:YGR162W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables ATPase activator activity and RNA binding activity. Involved in several processes, including cellular response to glucose starvation; positive regulation of formation of translation preinitiation complex; and stress granule assembly. Located in P-body and cytoplasmic stress granule. Part of eukaryotic translation initiation factor 4F complex. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in late onset Parkinson's disease. Orthologous to several human genes including EIF4G2 (eukaryotic translation initiation factor 4 gamma 2). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See TIF4631 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (824059..826917)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene gag-pol fusion protein Neighboring gene gag protein Neighboring gene tRNA-Val Neighboring gene Gtr2p Neighboring gene tRNA-Arg Neighboring gene uncharacterized protein

Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Translational control of gene expression noise and its relationship to ageing in yeast. Carolina de Souza-Guerreiro T, et al. FEBS J, 2021 Apr. PMID 33090724
  2. eIF4G1 N-terminal intrinsically disordered domain is a multi-docking station for RNA, Pab1, Pub1, and self-assembly. Chaves-Arquero B, et al. Front Mol Biosci, 2022. PMID 36213119, Free PMC Article
  3. Functional overlap between eIF4G isoforms in Saccharomyces cerevisiae. Clarkson BK, et al. PLoS One, 2010 Feb 9. PMID 20161741, Free PMC Article
  4. Stabilization of eukaryotic initiation factor 4E binding to the mRNA 5'-Cap by domains of eIF4G. von Der Haar T, et al. J Biol Chem, 2000 Sep 29. PMID 10887196
  5. Structural and functional similarities between the central eukaryotic initiation factor (eIF)4A-binding domain of mammalian eIF4G and the eIF4A-binding domain of yeast eIF4G. Dominguez D, et al. Biochem J, 2001 Apr 1. PMID 11256967, Free PMC Article

See all (193) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results indicate that putative serine/threonine protein kinase KSP1 (Ksp1) directly phosphorylates eukaryotic translation initiation factor 4G (eIF4G).
    Title: Ksp1-dependent phosphorylation of eIF4G modulates post-transcriptional regulation of specific mRNAs under glucose deprivation conditions.
  2. Pub1p C-terminal RRM domain interacts with Tif4631p through a conserved region neighbouring the Pab1p binding site
    Title: Pub1p C-terminal RRM domain interacts with Tif4631p through a conserved region neighbouring the Pab1p binding site.
  3. The RNA-binding region (RNA1) in the N-terminal domain (NTD) of yeast eIF4G1 can functionally substitute for the PABP-binding segment to rescue the function of an eIF4G1-459 mutant impaired for eIF4E binding.
    Title: Multiple elements in the eIF4G1 N-terminus promote assembly of eIF4G1•PABP mRNPs in vivo.
  4. Data show that that deletion of eIF4G1, but not eIF4G2, impairs growth and global translation initiation rates.
    Title: Functional overlap between eIF4G isoforms in Saccharomyces cerevisiae.
  5. involvement of yeast eIF4G in pre-mRNA metabolism; Tif4631p and Tif4632p interact efficiently with U1 snRNA; Tif4631p and Tif4632p associate with protein components of the splicing machinery, namely Snu71p and Prp11p.
    Title: Interaction of yeast eIF4G with spliceosome components: implications in pre-mRNA processing events.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATPase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding EXP
Inferred from Experiment
more info
 PubMed 
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding HDA PubMed 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular condensate scaffold activity EXP
Inferred from Experiment
more info
 PubMed 
enables molecular condensate scaffold activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cellular response to glucose starvation IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to glucose starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of endoplasmic reticulum unfolded protein response IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of formation of translation preinitiation complex IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of protein metabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of translational initiation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in ribosomal large subunit biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in stress granule assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in stress granule assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translational initiation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational initiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in P-body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in P-body IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm EXP
Inferred from Experiment
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic stress granule HDA PubMed 
located_in cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic stress granule IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic translation initiation factor 4F complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of eukaryotic translation initiation factor 4F complex IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic translation initiation factor 4F complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of eukaryotic translation initiation factor 4F complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in ribosome NAS
Non-traceable Author Statement
more info
 PubMed 
Preferred Names
translation initiation factor eIF4G
NP_011678.3
  • Translation initiation factor eIF4G and scaffold protein; subunit of the mRNA cap-binding protein complex (eIF4F) with eIF4E (Cdc33p) and eIF4A (Tif1p/Tif2p); stimulates the ATPase and helicase activities of eIF4A synergistically with eIF4G; required with eIF4E for Ded1p-mediated stimulation of mRNA recruitment during 48S preinitiation complex (PIC) assembly; association with Pab1p mediates poly(A) tail-stimulated translation; role in assembly of PET region in biogenesis of 60S ribosomal subunit

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    824059..826917
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181291.3 → NP_011678.3  translation initiation factor eIF4G

    See identical proteins and their annotated locations for NP_011678.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUU6, P39935
    UniProtKB/TrEMBL
    B3LI68, C7GQ70, C8Z957, N1P2E4
    Conserved Domains (4) summary
    PTZ00121
    Location:133 → 362
    PTZ00121; MAEBL; Provisional
    TIGR01622
    Location:489 → 562
    SF-CC1; splicing factor, CC1-like family
    pfam02854
    Location:607 → 850
    MIF4G; MIF4G domain
    pfam12152
    Location:411 → 469
    eIF_4G1; Eukaryotic translation initiation factor 4G1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P39935.2

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