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CYS4 cystathionine beta-synthase CYS4 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853059, updated on 18-Jan-2023

Summary

Gene symbol
CYS4
Gene description
cystathionine beta-synthase CYS4
Primary source
SGD:S000003387
Locus tag
YGR155W
See related
AllianceGenome:SGD:S000003387
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
NHS5; STR4; VMA41
Summary
Enables cystathionine beta-synthase activity. Involved in cysteine metabolic process; hydrogen sulfide biosynthetic process; and traversing start control point of mitotic cell cycle. Located in cytoplasm. Used to study homocystinuria. Human ortholog(s) of this gene implicated in coronary artery disease; homocystinuria; hyperhomocysteinemia; malaria; and neural tube defect. Orthologous to human CBS (cystathionine beta-synthase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See CYS4 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (798543..800066)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene omega-class glutathione transferase Neighboring gene cleavage polyadenylation factor subunit PTI1 Neighboring gene phosphatidylethanolamine N-methyltransferase

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the CYS4 gene: The CYS4 gene is conserved in human, chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, S.cerevisiae, K.lactis, E.gossypii, M.oryzae, N.crassa, rice, and frog.
  • Orthologs

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables cystathionine beta-synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cystathionine beta-synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cystathionine beta-synthase activity IEA
Inferred from Electronic Annotation
more info
 
enables cystathionine beta-synthase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables cysteine synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables mRNA binding HDA PubMed 

General protein information

Preferred Names
cystathionine beta-synthase CYS4
NP_011671.3
  • Cystathionine beta-synthase; catalyzes synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis; responsible for hydrogen sulfide generation; advances passage through START by promoting cell growth which requires catalytic activity, and reducing critical cell size independent of catalytic activity; mutations in human ortholog CBS cause homocystinuria; human CBS can complement yeast null mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    798543..800066
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181284.3NP_011671.3  TPA: cystathionine beta-synthase CYS4 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011671.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P32582, Q27JK4
    UniProtKB/TrEMBL
    A0A7I9ERF1, C7GQ63, C8Z949, G2WEN5, N1P5Z1
    Conserved Domains (1) summary
    TIGR01137
    Location:10507
    cysta_beta; cystathionine beta-synthase