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CYS4 cystathionine beta-synthase CYS4 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853059, updated on 18-Sep-2024

Summary

Official Symbol
CYS4
Official Full Name
cystathionine beta-synthase CYS4
Primary source
SGD:S000003387
Locus tag
YGR155W
See related
AllianceGenome:SGD:S000003387; FungiDB:YGR155W; VEuPathDB:YGR155W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
NHS5; STR4; VMA41
Summary
Enables cystathionine beta-synthase activity. Involved in cysteine metabolic process; hydrogen sulfide biosynthetic process; and traversing start control point of mitotic cell cycle. Located in cytoplasm. Used to study homocystinuria. Human ortholog(s) of this gene implicated in coronary artery disease; homocystinuria; hyperhomocysteinemia; malaria; and neural tube defect. Orthologous to human CBS (cystathionine beta-synthase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See CYS4 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (798543..800066)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene omega-class glutathione transferase Neighboring gene cleavage polyadenylation factor subunit PTI1 Neighboring gene phosphatidylethanolamine N-methyltransferase

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables cystathionine beta-synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cystathionine beta-synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cystathionine beta-synthase activity IEA
Inferred from Electronic Annotation
more info
 
enables cystathionine beta-synthase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables mRNA binding HDA PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic stress granule HDA PubMed 
located_in mitochondrion HDA PubMed 

General protein information

Preferred Names
cystathionine beta-synthase CYS4
NP_011671.3
  • Cystathionine beta-synthase; catalyzes synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis; responsible for hydrogen sulfide generation; advances passage through START by promoting cell growth which requires catalytic activity, and reducing critical cell size independent of catalytic activity; mutations in human ortholog CBS cause homocystinuria; human CBS can complement yeast null mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    798543..800066
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181284.3NP_011671.3  TPA: cystathionine beta-synthase CYS4 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011671.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUT5, P32582, Q05177, Q27JK1, Q27JK4
    UniProtKB/TrEMBL
    A6ZUG6, B3LI75, B5VJ98, C7GQ63, C8Z949, G2WEN5, N1P5Z1
    Conserved Domains (1) summary
    TIGR01137
    Location:10507
    cysta_beta; cystathionine beta-synthase