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CBF2 Cbf2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853041, updated on 18-Sep-2024

Summary

Official Symbol
CBF2
Official Full Name
Cbf2p
Primary source
SGD:S000003372
Locus tag
YGR140W
See related
AllianceGenome:SGD:S000003372; FungiDB:YGR140W; VEuPathDB:YGR140W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CEP2; CSL5; CTF14; NDC10
Summary
Enables DNA binding activity, bending and centromeric DNA binding activity. Involved in mitotic spindle elongation and septin ring assembly. Located in condensed chromosome, centromeric region and spindle midzone. Part of CBF3 complex. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See CBF2 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (767429..770299)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Lsb1p Neighboring gene spermine transporter Neighboring gene Vps62p Neighboring gene Btn2p

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA binding, bending IDA
Inferred from Direct Assay
more info
PubMed 
enables centromeric DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in chromosome segregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitotic spindle elongation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in septin ring assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of CBF3 complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
 
located_in condensed chromosome, centromeric region IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in spindle IDA
Inferred from Direct Assay
more info
PubMed 
located_in spindle midzone IDA
Inferred from Direct Assay
more info
PubMed 
located_in spindle pole body IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Cbf2p
NP_011656.3
  • Essential kinetochore protein; component of the CBF3 multisubunit complex that binds to the CDEIII region of the centromere; Cbf2p also binds to the CDEII region possibly forming a different multimeric complex, ubiquitinated in vivo; sumoylated in an Mms21p-dependent manner; relative distribution to the spindle pole body decreases upon DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    767429..770299
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181269.3NP_011656.3  TPA: Cbf2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011656.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUS0, E9P954, P32504
    UniProtKB/TrEMBL
    B3LI90, C8Z933, N1P5X8
    Conserved Domains (2) summary
    cd11602
    Location:29506
    Ndc10; Ndc10 component of the yeast centromere-binding factor 3
    pfam12550
    Location:843922
    GCR1_C; Transcriptional activator of glycolytic enzymes