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PPT1 protein serine/threonine phosphatase [ Saccharomyces cerevisiae S288C ]

Gene ID: 853023, updated on 5-Jul-2025
Official Symbol
PPT1
Official Full Name
protein serine/threonine phosphatase
Primary source
SGD:S000003355
Locus tag
YGR123C
See related
AllianceGenome:SGD:S000003355; FungiDB:YGR123C; VEuPathDB:YGR123C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables protein serine/threonine phosphatase activity. Involved in protein dephosphorylation. Located in cytoplasm and nucleus. Orthologous to human PPP5C (protein phosphatase 5 catalytic subunit). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See PPT1 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (736662..738203, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene tRNA-Arg Neighboring gene tRNA-Ile Neighboring gene asparagine synthase (glutamine-hydrolyzing) 2

Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. An 18.3 kb DNA fragment from yeast chromosome VII carries four unknown open reading frames, the gene for an Asn synthase, remnants of Ty and three tRNA genes. Van Dyck L, et al. Yeast, 1997 Feb. PMID 9046098
  2. Global analysis of phosphoproteome regulation by the Ser/Thr phosphatase Ppt1 in Saccharomyces cerevisiae. Schreiber TB, et al. J Proteome Res, 2012 Apr 6. PMID 22369663
  3. Characterization of Saccharomyces cerevisiae protein Ser/Thr phosphatase T1 and comparison to its mammalian homolog PP5. Jeong JY, et al. BMC Cell Biol, 2003 Mar 28. PMID 12694636, Free PMC Article
  4. Expression, purification and refolding of the phosphatase domain of protein phosphatase 1 (Ppt1) from Saccharomyces cerevisiae. Suhre MH, et al. Int J Biol Macromol, 2006 Aug 15. PMID 16442612
  5. Conformational switching of the molecular chaperone Hsp90 via regulated phosphorylation. Soroka J, et al. Mol Cell, 2012 Feb 24. PMID 22365831

See all (58) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. finding show that regulation of the Hsf1 S608 phosphorylation status by reciprocal actions of CK2 and Ppt1 might play an important role to determine Hsf1 sensitivity towards ethanol stress
    Title: CK2-dependent inhibitory phosphorylation is relieved by Ppt1 phosphatase for the ethanol stress-specific activation of Hsf1 in Saccharomyces cerevisiae.
  2. Taken together, these data demonstrate that hyperphosphorylation of Hsf1p caused by loss of the PPT1 gene at least partly accounts for the defective stress response and high ethanol productivity of modern sake yeast strains.
    Title: Association of constitutive hyperphosphorylation of Hsf1p with a defective ethanol stress response in Saccharomyces cerevisiae sake yeast strains.
  3. The phosphatase Ppt1 is a dedicated regulator of the molecular chaperone Hsp90.
    Title: The phosphatase Ppt1 is a dedicated regulator of the molecular chaperone Hsp90.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein dephosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
protein serine/threonine phosphatase
NP_011639.3
  • Protein serine/threonine phosphatase; regulates Hsp90 chaperone by affecting its ATPase and cochaperone binding activities; has similarity to human phosphatase PP5; present in both the nucleus and cytoplasm; expressed during logarithmic growth

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    736662..738203 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181252.3 → NP_011639.3  TPA: protein serine/threonine phosphatase

    See identical proteins and their annotated locations for NP_011639.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUQ5, P53043
    UniProtKB/TrEMBL
    A6ZUD7, B3LIA5, B5VJ69, C7GUH2, C8Z916, N1P3Q7
    Conserved Domains (3) summary
    PLN03088
    Location:10 → 130
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
    sd00006
    Location:12 → 40
    TPR; TPR repeat [structural motif]
    cd07417
    Location:165 → 508
    MPP_PP5_C; PP5, C-terminal metallophosphatase domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53043.1

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