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RPS23A 40S ribosomal protein uS12 RPS23A [ Saccharomyces cerevisiae S288C ]

Gene ID: 853015, updated on 15-Feb-2026
Official Symbol
RPS23A
Official Full Name
40S ribosomal protein uS12 RPS23A
Primary source
SGD:S000003350
Locus tag
YGR118W
See related
AllianceGenome:SGD:S000003350; FungiDB:YGR118W; VEuPathDB:YGR118W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
A structural constituent of ribosome. Involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and regulation of translational fidelity. Part of cytosolic small ribosomal subunit. Human ortholog(s) of this gene implicated in brachycephaly, trichomegaly, and developmental delay. Orthologous to human RPS23 (ribosomal protein S23). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
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Location:
chromosome: VII
Exon count:
2
Sequence:
Chromosome: VII; NC_001139.9 (726974..727730)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene chromatin-remodeling histone chaperone SPT6 Neighboring gene uncharacterized protein Neighboring gene FG-nucleoporin NUP57 Neighboring gene Golgi transport complex subunit COG2

Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The sequence of a 23.4 kb segment on the right arm of chromosome VII from Saccharomyces cerevisiae reveals CLB6, SPT6, RP28A and NUP57 genes, a Ty3 element and 11 new open reading frames. Hansen M, et al. Yeast, 1996 Sep 30. PMID 8905931
  2. A novel cloning strategy reveals the gene for the yeast homologue to Escherichia coli ribosomal protein S12. Alksne LE, et al. J Biol Chem, 1993 May 25. PMID 8496146
  3. An accuracy center in the ribosome conserved over 2 billion years. Alksne LE, et al. Proc Natl Acad Sci U S A, 1993 Oct 15. PMID 8415737, Free PMC Article
  4. Structural insights into ribosomal rescue by Dom34 and Hbs1 at near-atomic resolution. Hilal T, et al. Nat Commun, 2016 Dec 20. PMID 27995908, Free PMC Article
  5. Mutations in yeast ribosomal proteins S28 and S4 affect the accuracy of translation and alter the sensitivity of the ribosomes to paromomycin. Synetos D, et al. Biochim Biophys Acta, 1996 Nov 11. PMID 8950190

See all (97) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in maintenance of translational fidelity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of translational fidelity IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of translational fidelity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of cytosolic small ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic small ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  
part_of small ribosomal subunit IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
40S ribosomal protein uS12 RPS23A
NP_011633.3
  • Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit; required for translational accuracy; homologous to mammalian ribosomal protein S23 and bacterial S12; RPS23A has a paralog, RPS23B, that arose from the whole genome duplication; deletion of both RPS23A and RPS23B is lethal

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    726974..727730
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181247.3 → NP_011633.3  40S ribosomal protein uS12 RPS23A

    See identical proteins and their annotated locations for NP_011633.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUP9, P0CX29, P0CX30, P32827
    UniProtKB/TrEMBL
    A6ZUD1, B3LIB1, C8Z909, C8ZJF4, G2WEK0, N1P5W3
    Conserved Domains (1) summary
    PTZ00067
    Location:4 → 145
    PTZ00067; 40S ribosomal S23; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0CX29.1
P0CX30.1

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Other Literature Sources
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Research Materials
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