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SPT6 chromatin-remodeling histone chaperone SPT6 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853011, updated on 23-Apr-2026
Official Symbol
SPT6
Official Full Name
chromatin-remodeling histone chaperone SPT6
Primary source
SGD:S000003348
Locus tag
YGR116W
See related
AllianceGenome:SGD:S000003348; FungiDB:YGR116W; VEuPathDB:YGR116W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CRE2; SSN20
Summary
Enables histone binding activity; nucleosome binding activity; and transcription antitermination factor activity, DNA binding. Involved in several processes, including G1/S transition of mitotic cell cycle; gene expression; and regulation of RNA metabolic process. Located in euchromatin and nucleus. Orthologous to human SUPT6H (SPT6 homolog, histone chaperone and transcription elongation factor). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
all
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See SPT6 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (720409..724764)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene cytochrome oxidase assembly protein SHY1 Neighboring gene Dam1p Neighboring gene uncharacterized protein Neighboring gene 40S ribosomal protein uS12 RPS23A

Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Genome-wide regulation of Pol II, FACT, and Spt6 occupancies by RSC in Saccharomyces cerevisiae.
    Title: Genome-wide regulation of Pol II, FACT, and Spt6 occupancies by RSC in Saccharomyces cerevisiae.
  2. Spt6 directly interacts with Cdc73 and is required for Paf1 complex occupancy at active genes in Saccharomyces cerevisiae.
    Title: Spt6 directly interacts with Cdc73 and is required for Paf1 complex occupancy at active genes in Saccharomyces cerevisiae.
  3. The conserved histone chaperone Spt6 is strongly required for DNA replication and genome stability.
    Title: The conserved histone chaperone Spt6 is strongly required for DNA replication and genome stability.
  4. Spn1 and Its Dynamic Interactions with Spt6, Histones and Nucleosomes.
    Title: Spn1 and Its Dynamic Interactions with Spt6, Histones and Nucleosomes.
  5. Cooperation between intrinsically disordered and ordered regions of Spt6 regulates nucleosome and Pol II CTD binding, and nucleosome assembly.
    Title: Cooperation between intrinsically disordered and ordered regions of Spt6 regulates nucleosome and Pol II CTD binding, and nucleosome assembly.
  6. The histone chaperone Spt6 is required for normal recruitment of the capping enzyme Abd1 to transcribed regions.
    Title: The histone chaperone Spt6 is required for normal recruitment of the capping enzyme Abd1 to transcribed regions.
  7. Core promoter activity contributes to chromatin-based regulation of internal cryptic promoters.
    Title: Core promoter activity contributes to chromatin-based regulation of internal cryptic promoters.
  8. Yeast Spt6 Reads Multiple Phosphorylation Patterns of RNA Polymerase II C-Terminal Domain In Vitro.
    Title: Yeast Spt6 Reads Multiple Phosphorylation Patterns of RNA Polymerase II C-Terminal Domain In Vitro.
  9. The conserved elongation factor Spn1 is required for normal transcription, histone modifications, and splicing in Saccharomyces cerevisiae.
    Title: The conserved elongation factor Spn1 is required for normal transcription, histone modifications, and splicing in Saccharomyces cerevisiae.
  10. Histone Recycling by FACT and Spt6 during Transcription Prevents the Scrambling of Histone Modifications.
    Title: Histone Recycling by FACT and Spt6 during Transcription Prevents the Scrambling of Histone Modifications.
Submit: New GeneRIF Correction See all GeneRIFs (30)
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables nucleosome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleosome binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables nucleosome binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription antitermination factor activity, DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription antitermination factor activity, DNA binding IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables transcription antitermination factor activity, DNA binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in chromatin remodeling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleosome assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nucleosome organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nucleosome organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in poly(A)+ mRNA export from nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription elongation by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of mRNA 3'-end processing IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of mRNA 3'-end processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transcription antitermination IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in transcription antitermination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transcription elongation by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription elongation-coupled chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in euchromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of transcription elongation factor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
chromatin-remodeling histone chaperone SPT6
NP_011631.1
  • Histone chaperone; regulates chromatin structure, transcription, mRNA 3'-end formation and genome stability; role in chromatin remodeling and nucleosome assembly; acidic intrinsically disordered NTD binds histones and controls chromatin structure; role in replication initiation, promoting origin licensing through MCM helicase loading; required for fidelity of transcriptional promoter selection through maintenance of chromatin structure; required for H3K36 trimethylation by Set2p

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    720409..724764
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181245.1 → NP_011631.1  chromatin-remodeling histone chaperone SPT6

    See identical proteins and their annotated locations for NP_011631.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUP7, P23615
    UniProtKB/TrEMBL
    A6ZUC9, B3LIB3, N1P9W5
    Conserved Domains (3) summary
    COG2183
    Location:346 → 1277
    Tex; Transcriptional accessory protein Tex/SPT6 [Transcription]
    pfam14632
    Location:28 → 128
    SPT6_acidic; Acidic N-terminal SPT6
    pfam14633
    Location:1232 → 1436
    SH2_2; SH2 domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P23615.1

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