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VOA1 Voa1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852998, updated on 3-Jun-2026
Official Symbol
VOA1
Official Full Name
Voa1p
Primary source
SGD:S000003338
Locus tag
YGR106C
See related
AllianceGenome:SGD:S000003338; FungiDB:YGR106C; VEuPathDB:YGR106C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in protein-containing complex assembly. Located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See VOA1 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (698989..699786, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Srb5p Neighboring gene Vma21p Neighboring gene tRNA-Leu Neighboring gene tRNA-Lys

Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Big1 is a newly identified autophagy regulator that is critical for a fully functional V-ATPase. Lei Y, et al. Mol Biol Cell, 2024 Nov 1. PMID 39259764, Free PMC Article
  2. ATP6AP1 deficiency causes an immunodeficiency with hepatopathy, cognitive impairment and abnormal protein glycosylation. Jansen EJ, et al. Nat Commun, 2016 May 27. PMID 27231034, Free PMC Article
  3. Chemical inhibitors of Candida albicans hyphal morphogenesis target endocytosis. Bar-Yosef H, et al. Sci Rep, 2017 Jul 18. PMID 28720834, Free PMC Article
  4. The 3.5-Å CryoEM Structure of Nanodisc-Reconstituted Yeast Vacuolar ATPase V(o) Proton Channel. Roh SH, et al. Mol Cell, 2018 Mar 15. PMID 29526695, Free PMC Article
  5. Voa1p functions in V-ATPase assembly in the yeast endoplasmic reticulum. Ryan M, et al. Mol Biol Cell, 2008 Dec. PMID 18799613, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables proton-transporting ATPase activity, rotational mechanism IC
Inferred by Curator
more info
 PubMed 
Process Evidence Code Pubs
involved_in Golgi lumen acidification NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in endosomal lumen acidification NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in protein-containing complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proton transmembrane transport IC
Inferred by Curator
more info
 PubMed 
involved_in proton transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in vacuolar acidification IC
Inferred by Curator
more info
 PubMed 
involved_in vacuolar acidification NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in fungal-type vacuole membrane HDA PubMed 
located_in fungal-type vacuole membrane NAS
Non-traceable Author Statement
more info
 PubMed 
part_of proton-transporting V-type ATPase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in vacuolar membrane EXP
Inferred from Experiment
more info
 PubMed 
located_in vacuolar membrane IEA
Inferred from Electronic Annotation
more info
  
part_of vacuolar proton-transporting V-type ATPase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of vacuolar proton-transporting V-type ATPase, V0 domain IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
Voa1p
NP_011620.1
  • ER protein that functions in assembly of the V0 sector of V-ATPase; functions with other assembly factors; null mutation enhances the vacuolar ATPase (V-ATPase) deficiency of a vma21 mutant impaired in endoplasmic reticulum (ER) retrieval

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    698989..699786 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181235.1 → NP_011620.1  Voa1p

    See identical proteins and their annotated locations for NP_011620.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUN8, P53262
    UniProtKB/TrEMBL
    A6ZV88, B3LIC0, B5VJ52, C7GWV7, G2WEJ1, N1P405
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53262.1

Gene LinkOut

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