RRP46 exosome non-catalytic core subunit RRP46 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: RRP46
Gene description: exosome non-catalytic core subunit RRP46
Primary source: SGD:S000003327
Locus tag: YGR095C
Gene type: protein coding
RNA name: exosome non-catalytic core subunit RRP46
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces

Genomic context

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See RRP46 in Genome Data Viewer

Location:: chromosome: VII

Exon count:: 1

Sequence:: Chromosome: VII; NC_001139.9 (675671..676342, complement)

Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Submit: New GeneRIF Correction

Pathways from BioSystems

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Deadenylation-dependent mRNA decay, organism-specific biosystem (from REACTOME)
Deadenylation-dependent mRNA decay, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Exosome, eukaryotes, organism-specific biosystem (from KEGG)
Exosome, eukaryotes, organism-specific biosystemStructural complex; Genetic information processing; RNA processing
Exosome, eukaryotes, conserved biosystem (from KEGG)
Exosome, eukaryotes, conserved biosystemStructural complex; Genetic information processing; RNA processing
Gene Expression, organism-specific biosystem (from REACTOME)
Gene Expression, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Major pathway of rRNA processing in the nucleolus and cytosol, organism-specific biosystem (from REACTOME)
Major pathway of rRNA processing in the nucleolus and cytosol, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RNA degradation, organism-specific biosystem (from KEGG)
RNA degradation, organism-specific biosystemThe correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay e...
RNA degradation, conserved biosystem (from KEGG)
RNA degradation, conserved biosystemThe correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay e...
mRNA decay by 3' to 5' exoribonuclease, organism-specific biosystem (from REACTOME)
mRNA decay by 3' to 5' exoribonuclease, organism-specific biosystemcomputationally inferred pathway (not manually curated)
rRNA processing, organism-specific biosystem (from REACTOME)
rRNA processing, organism-specific biosystemcomputationally inferred pathway (not manually curated)
rRNA processing in the nucleus and cytosol, organism-specific biosystem (from REACTOME)
rRNA processing in the nucleus and cytosol, organism-specific biosystemcomputationally inferred pathway (not manually curated)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

The Hierarchical Catalog of Orthologs

Gene Ontology Provided by GO

Function	Evidence Code	Pubs
RNA binding	IEA Inferred from Electronic Annotation more info
molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
U4 snRNA 3'-end processing	IBA Inferred from Biological aspect of Ancestor more info	PubMed
exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IMP Inferred from Mutant Phenotype more info	PubMed
ncRNA 3'-end processing	IC Inferred by Curator more info	PubMed
nonfunctional rRNA decay	IC Inferred by Curator more info	PubMed
nuclear mRNA surveillance	IBA Inferred from Biological aspect of Ancestor more info	PubMed
nuclear polyadenylation-dependent mRNA catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
nuclear polyadenylation-dependent rRNA catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
nuclear polyadenylation-dependent tRNA catabolic process	IDA Inferred from Direct Assay more info	PubMed
nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay	IC Inferred by Curator more info	PubMed
nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'	IBA Inferred from Biological aspect of Ancestor more info	PubMed
nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'	IC Inferred by Curator more info	PubMed
nuclear-transcribed mRNA catabolic process, non-stop decay	IC Inferred by Curator more info	PubMed
polyadenylation-dependent snoRNA 3'-end processing	IBA Inferred from Biological aspect of Ancestor more info	PubMed
polyadenylation-dependent snoRNA 3'-end processing	IC Inferred by Curator more info	PubMed
rRNA catabolic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
rRNA processing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cytoplasm	IEA Inferred from Electronic Annotation more info
cytoplasmic exosome (RNase complex)	IBA Inferred from Biological aspect of Ancestor more info	PubMed
cytoplasmic exosome (RNase complex)	IDA Inferred from Direct Assay more info	PubMed
exosome (RNase complex)	IEA Inferred from Electronic Annotation more info
nuclear exosome (RNase complex)	IBA Inferred from Biological aspect of Ancestor more info	PubMed
nuclear exosome (RNase complex)	IDA Inferred from Direct Assay more info	PubMed
nucleolus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
nucleolus	IEA Inferred from Electronic Annotation more info
nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: exosome non-catalytic core subunit RRP46

NP_011609.2

Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp46p (EXOSC5)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001139.9 Reference assembly

Range

675671..676342 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181224.1 → NP_011609.2 TPA: exosome non-catalytic core subunit RRP46 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011609.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P53256

Conserved Domains (1) summary

cd11372
Location:4 → 210

RNase_PH_RRP46; RRP46 subunit of eukaryotic exosome