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NNF2 Nnf2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852980, updated on 18-Sep-2024

Summary

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Official Symbol
NNF2
Official Full Name
Nnf2p
Primary source
SGD:S000003321
Locus tag
YGR089W
See related
AllianceGenome:SGD:S000003321; FungiDB:YGR089W; VEuPathDB:YGR089W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1Y; familial hypertrophic cardiomyopathy; and hypertrophic cardiomyopathy 3. Orthologous to human TPM1 (tropomyosin 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See NNF2 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (656960..659770)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene indolepyruvate decarboxylase 6 Neighboring gene catalase T Neighboring gene ncRNA Neighboring gene tRNA-Thr

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Physiological importance and identification of novel targets for the N-terminal acetyltransferase NatB. Caesar R, et al. Eukaryot Cell, 2006 Feb. PMID 16467477, Free PMC Article
  2. Proteome-wide remodeling of protein location and function by stress. Lee K, et al. Proc Natl Acad Sci U S A, 2014 Jul 29. PMID 25028499, Free PMC Article
  3. Partners of Rpb8p, a small subunit shared by yeast RNA polymerases I, II and III. Briand JF, et al. Mol Cell Biol, 2001 Sep. PMID 11486042, Free PMC Article
  4. Predicting protein functions from redundancies in large-scale protein interaction networks. Samanta MP, et al. Proc Natl Acad Sci U S A, 2003 Oct 28. PMID 14566057, Free PMC Article
  5. A computationally directed screen identifying interacting coiled coils from Saccharomyces cerevisiae. Newman JR, et al. Proc Natl Acad Sci U S A, 2000 Nov 21. PMID 11087867, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Nnf2p
NP_011603.1
  • Protein that exhibits physical and genetic interactions with Rpb8p; Rpb8p is a subunit of RNA polymerases I, II, and III; computational analysis of large-scale protein-protein interaction data suggests a role in chromosome segregation

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    656960..659770
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181218.1 → NP_011603.1  TPA: Nnf2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011603.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUM1, P53253
    UniProtKB/TrEMBL
    B5VJ33
    Conserved Domains (1) summary
    COG1196
    Location:818 → 932
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53253.1

Gene LinkOut

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