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PEX8 Pex8p [ Saccharomyces cerevisiae S288C ]

Gene ID: 852968, updated on 5-Jul-2025
Official Symbol
PEX8
Official Full Name
Pex8p
Primary source
SGD:S000003309
Locus tag
YGR077C
See related
AllianceGenome:SGD:S000003309; FungiDB:YGR077C; VEuPathDB:YGR077C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
PAS6
Summary
Enables protein-macromolecule adaptor activity. Involved in protein import into peroxisome matrix. Part of peroxisomal importomer complex. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (637744..639513, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene mRNA splicing protein SMD1 Neighboring gene U4/U6-U5 snRNP complex subunit PRP38 Neighboring gene mitochondrial 54S ribosomal protein mL59 MRPL25 Neighboring gene tubulin-binding prefolding complex subunit PAC10 Neighboring gene uncharacterized protein

Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Multiple targeting modules on peroxisomal proteins are not redundant: discrete functions of targeting signals within Pmp47 and Pex8p. Wang X, et al. Mol Biol Cell, 2004 Apr. PMID 14742703, Free PMC Article
  2. Pex8p, an intraperoxisomal peroxin of Saccharomyces cerevisiae required for protein transport into peroxisomes binds the PTS1 receptor pex5p. Rehling P, et al. J Biol Chem, 2000 Feb 4. PMID 10652355
  3. Saccharomyces cerevisiae PTS1 receptor Pex5p interacts with the SH3 domain of the peroxisomal membrane protein Pex13p in an unconventional, non-PXXP-related manner. Bottger G, et al. Mol Biol Cell, 2000 Nov. PMID 11071920, Free PMC Article
  4. The peroxisomal importomer constitutes a large and highly dynamic pore. Meinecke M, et al. Nat Cell Biol, 2010 Mar. PMID 20154681
  5. Isolation of peroxisome assembly mutants from Saccharomyces cerevisiae with different morphologies using a novel positive selection procedure. Van der Leij I, et al. J Cell Biol, 1992 Oct. PMID 1356111, Free PMC Article

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables protein-macromolecule adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in peroxisome organization IEA
Inferred from Electronic Annotation
more info
  
involved_in protein import into peroxisome matrix IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of peroxisomal importomer complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in peroxisomal matrix IEA
Inferred from Electronic Annotation
more info
  
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
Pex8p
NP_011591.1
  • Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    637744..639513 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181206.1 → NP_011591.1  TPA: Pex8p

    See identical proteins and their annotated locations for NP_011591.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUK9, P53248
    UniProtKB/TrEMBL
    A6ZV59, B3LIE9, B5VJ18, C8Z8X1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53248.1

Gene LinkOut

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