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ERG25 methylsterol monooxygenase [ Saccharomyces cerevisiae S288C ]

Gene ID: 852951, updated on 27-Feb-2020

Summary

Gene symbol
ERG25
Gene description
methylsterol monooxygenase
Primary source
SGD:S000003292
Locus tag
YGR060W
Gene type
protein coding
RNA name
methylsterol monooxygenase
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces

Genomic context

See ERG25 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (610564..611493)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene septin SPR3 Neighboring gene ncRNA Neighboring gene phosphoribosylformylglycinamidine synthase Neighboring gene membrane insertase COX18

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the ERG25 gene: The ERG25 gene is conserved in dog, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, and rice.

Gene Ontology Provided by GO

Function Evidence Code Pubs
C-4 methylsterol oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
C-4 methylsterol oxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
C-4 methylsterol oxidase activity IEA
Inferred from Electronic Annotation
more info
 
iron ion binding IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
ergosterol biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ergosterol biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
lipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
steroid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
steroid metabolic process IEA
Inferred from Electronic Annotation
more info
 
sterol biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
methylsterol monooxygenase
NP_011574.3
  • C-4 methyl sterol oxidase; catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants accumulate the sterol intermediate 4,4-dimethylzymosterol; human MSMO1 functionally complements the growth defect caused by repression of ERG25 expression

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    610564..611493
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181189.3NP_011574.3  TPA: methylsterol monooxygenase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011574.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P53045
    Conserved Domains (1) summary
    COG3000
    Location:35307
    ERG3; Sterol desaturase/sphingolipid hydroxylase, fatty acid hydroxylase superfamily [Lipid transport and metabolism]
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