RSC1 RSC subunit protein RSC1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: RSC1
Official Full Name: RSC subunit protein RSC1
Primary source: SGD:S000003288
Locus tag: YGR056W
See related: AllianceGenome:SGD:S000003288; FungiDB:YGR056W; VEuPathDB:YGR056W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Predicted to enable chromatin binding activity. Predicted to contribute to ATP-dependent activity, acting on DNA. Involved in double-strand break repair via nonhomologous end joining; nucleosome disassembly; and transcription elongation by RNA polymerase II. Part of RSC-type complex. Human ortholog(s) of this gene implicated in extrahepatic bile duct adenocarcinoma; lung non-small cell carcinoma; lung small cell carcinoma; and renal cell carcinoma. Orthologous to human PBRM1 (polybromo 1). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Genomic context

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See RSC1 in Genome Data Viewer

Location:: chromosome: VII

Exon count:: 1

Sequence:: Chromosome: VII; NC_001139.9 (601661..604447)

Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Single-molecule imaging of chromatin remodelers reveals role of ATPase in promoting fast kinetics of target search and dissociation from chromatin.
Title: Single-molecule imaging of chromatin remodelers reveals role of ATPase in promoting fast kinetics of target search and dissociation from chromatin.
Specialization of the chromatin remodeler RSC to mobilize partially-unwrapped nucleosomes.
Title: Specialization of the chromatin remodeler RSC to mobilize partially-unwrapped nucleosomes.
It has been shown that RSC does not affect the nucleosomal occupancy at CUP1. Therefore, transient binding of Ace1p and rapid bursts of transcription at CUP1 may be dependent on short repetitive cycles of nucleosome mobilization.
Title: Single-Molecule Analysis Reveals Linked Cycles of RSC Chromatin Remodeling and Ace1p Transcription Factor Binding in Yeast.
The chromatin remodelers RSC and ISW1 display functional and chromatin-based promoter antagonism.
Title: The chromatin remodelers RSC and ISW1 display functional and chromatin-based promoter antagonism.
Using a yeast extract in vitro reconstitution system that generates in vivo-like nucleosome patterns at Saccharomyces cerevisiae loci, the authors find that the RSC chromatin remodelling enzyme is necessary for nucleosome positioning.
Title: The RSC chromatin remodelling enzyme has a unique role in directing the accurate positioning of nucleosomes.
Data show that RSC1 and RSC2 are haploinsufficient for spore formation in a smk1 hypomorph.
Title: RSC1 and RSC2 are required for expression of mid-late sporulation-specific genes in Saccharomyces cerevisiae.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
contributes_to ATP-dependent activity, acting on DNA	IC Inferred by Curator more info	PubMed
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in double-strand break repair via nonhomologous end joining	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair via nonhomologous end joining	IPI Inferred from Physical Interaction more info	PubMed
involved_in nucleosome disassembly	IDA Inferred from Direct Assay more info	PubMed
involved_in nucleosome disassembly	IEA Inferred from Electronic Annotation more info
involved_in regulation of sporulation resulting in formation of a cellular spore	IEA Inferred from Electronic Annotation more info
involved_in sporulation resulting in formation of a cellular spore	IEA Inferred from Electronic Annotation more info
involved_in transcription elongation by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in transcription elongation by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in transcription elongation by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of RSC-type complex	IBA Inferred from Biological aspect of Ancestor more info
part_of RSC-type complex	IDA Inferred from Direct Assay more info	PubMed
part_of RSC-type complex	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: RSC subunit protein RSC1

NP_011570.1

Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; contains two essential bromodomains, a bromo-adjacent homology (BAH) domain, and an AT hook; RSC1 has a paralog, RSC2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001139.9 Reference assembly

Range

601661..604447

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181185.1 → NP_011570.1 TPA: RSC subunit protein RSC1

See identical proteins and their annotated locations for NP_011570.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VUJ1, P53236, Q45U30

UniProtKB/TrEMBL

N1P250

Conserved Domains (2) summary

cd05521
Location:8 → 113

Bromo_Rsc1_2_I; Bromodomain, repeat I in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are components of the RSC complex (remodeling the structure of chromatin), are essential for transcriptional control, and have a specific domain architecture including two ...

COG5076
Location:115 → 463

COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]