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KRTAP2-4 keratin associated protein 2-4 [ Homo sapiens (human) ]

Gene ID: 85294, updated on 18-Aug-2020

Summary

Official Symbol
KRTAP2-4provided by HGNC
Official Full Name
keratin associated protein 2-4provided by HGNC
Primary source
HGNC:HGNC:18891
See related
Ensembl:ENSG00000213417
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KAP2.3; KAP2.4; KAP2.1B; KRTAP2-3; KRTAP2.3; KRTAP2.4
Summary
This protein is a member of the keratin-associated protein (KAP) family. The KAP proteins form a matrix of keratin intermediate filaments which contribute to the structure of hair fibers. KAP family members appear to have unique, family-specific amino- and carboxyl-terminal regions and are subdivided into three multi-gene families according to amino acid composition: the high sulfur, the ultrahigh sulfur, and the high tyrosine/glycine KAPs. This protein is a member of the high sulfur KAP family and the gene is localized to a cluster of KAPs at 17q12-q21. [provided by RefSeq, Jul 2008]
Orthologs

Genomic context

See KRTAP2-4 in Genome Data Viewer
Location:
17q21.2
Exon count:
1
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (41065116..41065879, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (39221368..39222131, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene keratin associated protein 2-2 Neighboring gene keratin associated protein 2-3 Neighboring gene keratin associated protein 2-5, pseudogene Neighboring gene keratin associated protein 4-7

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC74790, MGC119882, MGC119884, MGC119885

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
keratinization TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
keratin filament IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
keratin-associated protein 2-4
Names
Keratin-associated protein 2-3
Keratin-associated protein 2.3
high sulfur keratin-associated protein 2.4
keratin associated protein 2.1B
keratin-associated protein 2.4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033184.4NP_149440.1  keratin-associated protein 2-4

    See identical proteins and their annotated locations for NP_149440.1

    Status: REVIEWED

    Source sequence(s)
    AJ406930
    Consensus CDS
    CCDS32648.1
    UniProtKB/Swiss-Prot
    P0C7H8, Q9BYR9
    Related
    ENSP00000377583.2, ENST00000394015.3
    Conserved Domains (2) summary
    pfam01500
    Location:2128
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam13885
    Location:73117
    Keratin_B2_2; Keratin, high sulfur B2 protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    41065116..41065879 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NW_003871091.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    214614..215377 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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