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GSC2 1,3-beta-glucan synthase GSC2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852920, updated on 23-Jul-2026
Official Symbol
GSC2
Official Full Name
1,3-beta-glucan synthase GSC2
Primary source
SGD:S000003264
Locus tag
YGR032W
See related
AllianceGenome:SGD:S000003264; FungiDB:YGR032W; VEuPathDB:YGR032W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
FKS2
Summary
Enables 1,3-beta-D-glucan synthase activity. Involved in (1->3)-beta-D-glucan biosynthetic process and ascospore wall assembly. Located in prospore membrane. Part of 1,3-beta-D-glucan synthase complex. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See GSC2 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (548264..553951)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene ribonuclease P/MRP protein subunit POP6 Neighboring gene Imo32p Neighboring gene Nag1p Neighboring gene Tim21p Neighboring gene 60S ribosomal protein uL24 RPL26B

Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Biosynthesis of the yeast cell wall. II. Regulation of beta-(1 leads to 3)glucan synthetase by ATP and GTP. Shematek EM, et al. J Biol Chem, 1980 Feb 10. PMID 6766140
  2. Unilateral angiofibromas. An oligosymptomatic and segmentary form of tuberous sclerosis. Del Pozo J, et al. Eur J Dermatol, 2002 May-Jun. PMID 11989480
  3. Inhibition mechanism of the fungal β-1,3-glucan synthases by triterpenoid antifungal drugs. You ZL, et al. Nat Commun, 2026 Feb 4. PMID 41639077, Free PMC Article
  4. Characterization and gene cloning of 1,3-beta-D-glucan synthase from Saccharomyces cerevisiae. Inoue SB, et al. Eur J Biochem, 1995 Aug 1. PMID 7649185
  5. Differential sensitivity between Fks1p and Fks2p against a novel beta -1,3-glucan synthase inhibitor, aerothricin3 [corrected]. Kondoh O, et al. J Biol Chem, 2002 Nov 1. PMID 12202487

See all (112) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ste11 regulates the FKS2 gene through its substrates and through Mpk1.
    Title: Ste11p MEKK signals through HOG, mating, calcineurin and PKC pathways to regulate the FKS2 gene.
  2. The dimeric complex of Mpk1 binds to a Swi4 recognition site in the FKS2 promoter.[Mpk1, Swi4, FKS2]
    Title: Transcriptional reporters for genes activated by cell wall stress through a non-catalytic mechanism involving Mpk1 and SBF.
  3. negative regulation of GSC2 by SMK1 is important for spore wall deposition
    Title: The Smk1p MAP kinase negatively regulates Gsc2p, a 1,3-beta-glucan synthase, during spore wall morphogenesis in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 1,3-beta-D-glucan synthase activity EXP
Inferred from Experiment
more info
 PubMed 
enables 1,3-beta-D-glucan synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1,3-beta-D-glucan synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 1,3-beta-D-glucan synthase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in (1->3)-beta-D-glucan biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in (1->3)-beta-D-glucan biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in (1->3)-beta-D-glucan biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in (1->3)-beta-D-glucan biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ascospore wall assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in ascospore wall assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ascospore wall assembly NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in fungal-type cell wall polysaccharide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of 1,3-beta-D-glucan synthase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of 1,3-beta-D-glucan synthase complex IEA
Inferred from Electronic Annotation
more info
  
located_in cell periphery HDA PubMed 
located_in cellular bud neck HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in prospore membrane IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
1,3-beta-glucan synthase GSC2
NP_011546.3
  • Catalytic subunit of 1,3-beta-glucan synthase; involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; GSC2 has a paralog, FKS1, that arose from the whole genome duplication

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    548264..553951
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181161.3 → NP_011546.3  1,3-beta-glucan synthase GSC2

    See identical proteins and their annotated locations for NP_011546.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUG8, P40989, Q45U52
    UniProtKB/TrEMBL
    B3LII8
    Conserved Domains (2) summary
    pfam02364
    Location:827 → 1650
    Glucan_synthase; 1,3-beta-glucan synthase component
    pfam14288
    Location:320 → 428
    FKS1_dom1; 1,3-beta-glucan synthase subunit FKS1, domain-1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40989.2

Gene LinkOut

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