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THG1 tRNA guanylyltransferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 852908, updated on 4-Aug-2021

Summary

Gene symbol
THG1
Gene description
tRNA guanylyltransferase
Primary source
SGD:S000003256
Locus tag
YGR024C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
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Genomic context

See THG1 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (531883..532596, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Mtl1p Neighboring gene tRNA Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the THG1 gene: The THG1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables tRNA guanylyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables tRNA guanylyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables tRNA guanylyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in tRNA 5'-end processing IEA
Inferred from Electronic Annotation
more info
 
involved_in tRNA modification IDA
Inferred from Direct Assay
more info
PubMed 
involved_in tRNA modification IEA
Inferred from Electronic Annotation
more info
 
involved_in tRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
tRNA guanylyltransferase
NP_011538.3
  • tRNAHis guanylyltransferase; adds a guanosine residue to the 5' end of tRNAH is after transcription and RNase P cleavage; can also catalyze reverse (3'-5') polymerization with certain substrates in a template-dependent reaction; couples nuclear division and migration to cell budding and cytokinesis; essential enzyme conserved among eukaryotes

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    531883..532596 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181153.3NP_011538.3  TPA: tRNA guanylyltransferase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011538.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P53215
    Conserved Domains (1) summary
    COG4021
    Location:2237
    Thg1; tRNA(His) 5'-end guanylyltransferase [Translation, ribosomal structure and biogenesis]
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