TFG2 transcription factor IIF subunit TFG2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: TFG2
Official Full Name: transcription factor IIF subunit TFG2
Primary source: SGD:S000003237
Locus tag: YGR005C
See related: AllianceGenome:SGD:S000003237; FungiDB:YGR005C; VEuPathDB:YGR005C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables RNA polymerase II complex binding activity. Involved in transcription elongation by RNA polymerase II and transcriptional start site selection at RNA polymerase II promoter. Part of transcription factor TFIIF complex. Orthologous to human GTF2F2 (general transcription factor IIF subunit 2). [provided by Alliance of Genome Resources, Jun 2025]
Orthologs: all
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Genomic context

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See TFG2 in Genome Data Viewer

Location:: chromosome: VII

Exon count:: 1

Sequence:: Chromosome: VII; NC_001139.9 (504657..505859, complement)

Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tfg2 C-terminal domain interacts with double-stranded DNA oligonucleotides.
Title: Structural and binding studies of the C-terminal domains of yeast TFIIF subunits Tfg1 and Tfg2.
Tfg2p is retained in the nucleus through DNA binding in Saccharomyces cerevisiae.
Title: Kap104p imports the PY-NLS-containing transcription factor Tfg2p into the nucleus.
We show that Anc1 is required for growth on galactose as the sole carbon source, and that it is recruited to the UAS of the GAL1 gene after induction.
Title: Anc1 interacts with the catalytic subunits of the general transcription factors TFIID and TFIIF, the chromatin remodeling complexes RSC and INO80, and the histone acetyltransferase complex NuA3.
Evidence that the Tfg1/Tfg2 dimer interface of TFIIF is located in proximity to the B-finger of TFIIB near the active center of RNA polymerase II (RNAP II) where the TFIIB-TFIIF-RNAP II interface plays a key role in transcription start site selection.
Title: Evidence that the Tfg1/Tfg2 dimer interface of TFIIF lies near the active center of the RNA polymerase II initiation complex.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II complex binding	IDA Inferred from Direct Assay more info	PubMed
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in transcription elongation by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in transcription initiation at RNA polymerase II promoter	IBA Inferred from Biological aspect of Ancestor more info
involved_in transcription initiation at RNA polymerase II promoter	IDA Inferred from Direct Assay more info	PubMed
involved_in transcription initiation at RNA polymerase II promoter	IEA Inferred from Electronic Annotation more info
involved_in transcriptional start site selection at RNA polymerase II promoter	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of transcription factor TFIIF complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription factor TFIIF complex	IDA Inferred from Direct Assay more info	PubMed
part_of transcription factor TFIIF complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transcription factor IIF subunit TFG2

NP_011519.3

TFIIF (Transcription Factor II) middle subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP30

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001139.9 Reference assembly

Range

504657..505859 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181134.3 → NP_011519.3 TPA: transcription factor IIF subunit TFG2 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011519.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VUE2, P41896

UniProtKB/TrEMBL

A6ZUZ7, B3LIL1, B5VIW6, C7GK75, C8Z8P9, G2WE98, N1P3E1

Conserved Domains (1) summary

COG5090
Location:33 → 400

TFG2; Transcription initiation factor IIF, small subunit (RAP30) [Transcription]