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SCL1 proteasome core particle subunit alpha 1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 852873, updated on 10-Mar-2023

Summary

Gene symbol
SCL1
Gene description
proteasome core particle subunit alpha 1
Primary source
SGD:S000002979
Locus tag
YGL011C
See related
AllianceGenome:SGD:S000002979
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
PRC2
Summary
Involved in proteasomal ubiquitin-independent protein catabolic process and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in mitochondrion. Part of proteasome core complex, alpha-subunit complex. Human ortholog(s) of this gene implicated in myocardial infarction. Orthologous to human PSMA6 (proteasome 20S subunit alpha 6). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See SCL1 in Genome Data Viewer
Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (474489..475247, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene drug-responsive transcription factor PDR1 Neighboring gene delta(24(24(1)))-sterol reductase Neighboring gene Mpo1p Neighboring gene 3-isopropylmalate dehydratase LEU1

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the SCL1 gene: The SCL1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
  • Orthologs

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Component Evidence Code Pubs
located_in cytoplasm IC
Inferred by Curator
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion HDA PubMed 
located_in nuclear outer membrane-endoplasmic reticulum membrane network IC
Inferred by Curator
more info
PubMed 
located_in nuclear outer membrane-endoplasmic reticulum membrane network IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IC
Inferred by Curator
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of proteasome complex IEA
Inferred from Electronic Annotation
more info
 
part_of proteasome core complex IEA
Inferred from Electronic Annotation
more info
 
part_of proteasome core complex, alpha-subunit complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of proteasome core complex, alpha-subunit complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of proteasome core complex, alpha-subunit complex IEA
Inferred from Electronic Annotation
more info
 
located_in proteasome storage granule IC
Inferred by Curator
more info
PubMed 
located_in proteasome storage granule IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
proteasome core particle subunit alpha 1
NP_011504.3
  • Alpha 1 subunit of the 20S proteasome; involved in the degradation of ubiquitinated substrates; 20S proteasome is the core complex of the 26S proteasome; essential for growth; detected in the mitochondria

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    474489..475247 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001180876.3NP_011504.3  TPA: proteasome core particle subunit alpha 1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011504.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P15708, P21243
    UniProtKB/TrEMBL
    A0A0L8VQJ0, A0A6A5PYC9, A0A6C1DSG9, A6ZUY2, B3LIM6, B5VIV2, C7GK62, C8Z8N2, G2WE82, H0GGD0, N1P3C8
    Conserved Domains (1) summary
    cd03754
    Location:12228
    proteasome_alpha_type_6; The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on top of one another forming ...